丝氨酸蛋白酶抑制剂通过细胞内吞作用参与调控细胞信号通路的机制的研究现状  

Current situation of the mechanism of the Serine protease inhibitor E2 involved in regulating cell signaling pathways through endocytosis

作　　者：陈双双 武靖 王愉靖 张明秀 杨瑞[1] 李雪连[1] CHEN Shuang-shuang;WU Jing;WANG Yu-jing;ZHANG Ming-xiu;YANG Rui;LI Xue-lian(Department of Pharmacology,College of Pharmacy,Key Laboratory of Cardiovascular Drug Research,Ministry of Education,Harbin Medical University,Harbin 150001,Heilongjiang Province,China;Clinical Pharmacy,First Affiliated Hospital,Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,Inner Mongolia,China)

机构地区：[1]哈尔滨医科大学药学院药理教研室、心血管药物研究教育部重点实验室,黑龙江哈尔滨150001 [2]内蒙古科技大学包头医学院第一附属医院临床药学室,内蒙古包头014010

出　　处：《中国临床药理学杂志》2021年第22期3189-3192,3203,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金面上基金资助项目(81870211);黑龙江省科学基金面上基金资助项目(H201402)。

摘　　要：丝氨酸蛋白酶抑制剂(SerpinE2)是丝氨酸蛋白酶抑制剂超家族中的一员,由多种细胞分泌,可作用于多种蛋白酶、蛋白激酶及参与调控细胞信号通路。SerpinE2在血液凝结、免疫反应、纤溶、血管生成、炎症和肿瘤等一系列生理病理过程中发挥着重要作用。本文主要介绍SerpinE2通过细胞内吞作用参与调控多种细胞信号通路的机制及其最新研究进展。Protease connexin-1(Serine protease inhibitor E2,SerpinE2)is a member of the serine protease inhibitor superfamily and is secreted by various cells which can effect on a variety of proteases,protein kinases and cell signaling pathways.SerpinE2 plays an important role in a series of physiological and pathological processes such as blood clotting,immune response,fibrinolysis,angiogenesis,inflammation and tumor suppression.This article mainly introduces the new mechanism and progress of SerpinE2 induced in regulating a variety of cellular signaling pathways through the cell endocytosis pathway.

关 键 词：蛋白酶连结蛋白-1 细胞内吞 信号通路 低密度脂蛋白受体相关蛋白1 硫酸乙酰肝素蛋白聚糖 

分 类 号：R97[医药卫生—药品]