细菌药物主动外排系统在生物被膜耐药中的作用  

Effect of bacterial efflux pump system on biofilm resistance

作　　者：王清会 凌保东[1] Wang Qing-hui;Ling Bao-dong(Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs,Chengdu Medical College,Chengdu 610500)

机构地区：[1]结构特异性小分子药物研究四川省高校重点实验室,成都医学院药学院,成都610500

出　　处：《中国抗生素杂志》2021年第10期917-921,共5页Chinese Journal of Antibiotics

基　　金：国家自然科学基金(No.81373454)。

摘　　要：细菌生物被膜的产生使传统抗菌药物难以对其进行有效的清除,进而导致严重感染的复发和持续性感染,是人类目前面临的又一新的挑战。生物被膜细菌中由于营养物质和代谢产物的积累,促使药物主动外排系统相关基因表达明显增加,使外排泵转运多种不同类型的化合物能力增强,从而产生多重耐药表型,是引起细菌耐药的主要机制之一;外排泵基因的表达对生物被膜细菌的生长和耐药性增强方面有着重要作用。本文从生物被膜耐药的影响因素、药物主动外排系统参与生物被膜形成及其影响、外排泵抑制剂对生物被膜耐药的影响几个方面对细菌药物主动外排系统在生物被膜耐药中的作用进行综述。The formation of bacterial biofilms makes it difficult for traditional antibacterial drugs to effectively remove them,which in turn leads to the recurrence of serious infections and persistent infections.It is yet another new global challenge facing humanity.The accumulation of nutrients and metabolic waste in the biofilm bacteria promotes a significant increase in the expression of related genes in the active efflux system of the drug,and enables the efflux pump to transport a variety of different types of compounds,resulting in multiple drug resistance phenotypes,which is caused by bacterial resistance one of the main mechanisms;the expression of efflux pump genes plays an important role in the growth of biofilm bacteria and the enhancement of drug resistance.In this paper,the factors affecting the biofilm resistance,the active drug efflux system participating in the biofilm formation and its impact,and the effect of the efflux pump inhibitor on the biofilm resistance are several aspects of resistance to the bacterial drug active efflux system in the biofilm.The role in the review is reviewed.

关 键 词：外排系统 生物被膜 细菌耐药 

分 类 号：R978.1[医药卫生—药品]