鸭疫里默氏菌毒力相关因子研究进展  

Progress on Virulence Related Factors in Riemerella Anatipestifer

作　　者：李林林 孙敏华 董嘉文 张俊勤 黄允真 黄瑜[2] 廖明[3] LI Lin-lin;SUN Min-hua;DONG Jia-wen;ZHANG Jun-qin;HUANG Yun-zhen;HUANG Yu;LIAO Ming(Institute of Animal Health,Guangdong Academy of Agricultural Sciences/Key Laboratory of Livestock Disease Prevention and Treatment of Guangdong Province/Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province,Ministry of Agriculture,Guangzhou Guangdong,510640,China;Fujian Provincial Key Laboratory for Avian Diseases Control and Prevention/Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agricultural Sciences,Fuzhou ,Fujian,350013,China;Guangdong Academy of Agricultural Sciences,Guangzhou,Guangdong,510640,China)

机构地区：[1]广东省农业科学院动物卫生研究所/农业农村部兽药与诊断学科群广东科学观测实验站/广东省畜禽疫病防治研究重点实验室,广东广州510640 [2]福建省禽病防治重点实验室/福建省农业科学院畜牧兽医研究所,福建福州350013 [3]广东省农业科学院,广东广州510640

出　　处：《动物医学进展》2021年第12期92-96,共5页Progress In Veterinary Medicine

基　　金：国家重点研发计划项目(2017YFD0500800);广东省自然科学基金温氏集团联合基金-重点项目(2018B030315002);福建省禽病防治重点实验室课题资助项目(FKADL-2019-01);广东省科技专项项目(DZX20192520301);广东省现代农业产业技术体系创新团队项目(2020KJ137)。

摘　　要：鸭疫里默氏菌(RA)是影响水禽养殖业的重要病原菌之一。该菌感染水禽后特征性病变有纤维素性心包炎、肝周炎和气囊炎。毒力因子在细菌致病过程中起着重要作用,论文主要阐述了近年来鸭疫里默氏菌致病性相关的毒力因子外膜蛋白、脂多糖、荚膜多糖、TonB蛋白、TonB依赖受体TbdR1、铁载体相互作用蛋白SIP、分泌系统相关因子和调控相关因子等的研究进展,并探讨了今后的研究方向,以期为鸭疫里默氏菌病的诊断、防治和相关疫苗研制提供参考。Riemerella anatipestifer(RA)is one of the important pathogens affecting the waterfowl industry.The characteristic pathological lesions of infected ducks are fibrinous pericarditis,pericarditis and air sacculitis.Virulence factors play an important role in the pathogenic process of the bacteria.In the current review,we mainly described the virulence factors related to the pathogenicity of R.anatipestifer in recent years,including outer membrane proteins,lipopolysaccharide,capsular polysaccharide,TonB protein,TonB dependent receptor tbdr1,siderophore-interacting protein SIP,secretory system related factors and regulatory related factors.Furthermore,we discussed future research directions,which further provided scientific reference for the diagnosis,control and related vaccine development of RA.

关 键 词：鸭疫里默氏菌 毒力因子 致病机制 

分 类 号：S852.612[农业科学—基础兽医学] S858.32[农业科学—兽医学]