维生素D干预影响2型糖尿病发病风险的Meta分析  

Effects of vitamin D supplementation on risk of type 2 diabetes mellitus:a Meta-analysis

作　　者：李彬[1] 金梦娜 丁教教[1] 李俊[1] LI Bin;JIN Mengna;DING Jiaojiao;LI Jun(Department of Transfusion,Taizhou Hospital of Zhejiang Province,Taizhou 317000,China)

机构地区：[1]浙江省台州医院输血科,317000

出　　处：《浙江医学》2021年第22期2449-2453,共5页Zhejiang Medical Journal

摘　　要：目的探讨补充维生素D对缺乏维生素D的非糖尿病人群2型糖尿病发病风险的影响。方法检索PubMed、Medline、Cochrane Library、EMbase、中国知网、万方、维普数据库、中国生物医学文献数据库等数据库从建库至2020年3月公开发表的关于补充维生素D对缺乏维生素D的非糖尿病人群2型糖尿病发病风险影响的随机对照研究。按照纳入与排除标准选择文献、提取资料和评价质量后,使用RevMan 5.3软件进行Meta分析。结果共纳入10篇文献39356例研究对象。Meta分析结果显示,与对照组相比,补充维生素D对缺乏维生素D的非糖尿病人群2型糖尿病发病风险差异无统计学意义(RR=0.97,95%CI:0.91~1.04,P>0.05)。而亚组分析则发现补充足剂量维生素D可降低上述人群的2型糖尿病发病风险(RR=0.87,95%CI:0.76~0.98,P<0.05)。结论补充足剂量维生素D可降低缺乏维生素D的非糖尿病人群2型糖尿病发病风险。Objective To evaluate the effects of vitamin D supplementation on risk of T2DM in non-diabetics with varying degrees of vitamin D deficiency.Methods The databases,including PubMed,MEDLINE,Cochrane,EMbase,CNKI,Wanfang Data,VIP,CMB were searched from the inception to March 2020 to retrieve random control trials on the effects of vitamin D supplementation on risk of T2DM in non-diabetics with varying degrees of vitamin D deficiency.The screening,data extraction and quality assessment were conducted in accordance with the inclusion and exclusion criteria,and Meta-analysis was performed by RevMan 5.3 software.Results Total 10 studies involving 39356 subjects were included for analysis.Meta-analysis showed that compared with the control group,vitamin D supplementation had no significant effect on the risk of T2DM in non-diabetics with varying degrees of vitamin D deficiency(RR=0.97,95%CI:0.91-1.04,P>0.05).However,subgroup analysis showed that sufficient vitamin D supplementation decreased the risk of T2DM in this group(RR=0.87,95%CI:0.76-0.98,P<0.05).Conclusion Sufficient vitamin D supplementation may reduce the risk of T2DM in non-diabetics with varying degrees of vitamin D deficiency.

关 键 词：维生素D 2型糖尿病 预防 META分析 

分 类 号：R587.1[医药卫生—内分泌]