2019年辽宁省33家医院血流感染病原菌及耐药率结果分析  

Analysis of pathogens associated with bloodstream infections and their respective resistance patterns conducted in 33 hospitals in Liaoning Province during 2019

作　　者：李富顺[1] 陈静静[1] 田素飞[1] 孙国全[1] 褚云卓[1] LI Fushun;CHEN Jingjing;TIAN Sufei;SUN Guoquan;CHU Yunzhuo(Department of Laboratory Medicine,The First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院检验科,沈阳110001

出　　处：《中国医科大学学报》2021年第11期1031-1035,1039,共6页Journal of China Medical University

摘　　要：目的探讨2019年辽宁地区血流感染病原菌分布及其耐药情况。方法选取辽宁省2019年1月至12月33家医院血培养分离株,按照全国细菌耐药监测网(CARSS)技术方案进行菌株鉴定及药物敏感性试验,采用Whonet 5.6软件对数据进行分析。结果2019年共分离细菌6584株,其中革兰氏阳性菌1508株(占22.8%),革兰氏阴性菌5082株(占77.2%),常见分离菌为大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌、屎肠球菌和鲍曼不动杆菌。耐甲氧西林金黄色葡萄球菌(MRSA)检出率为18.4%。大肠埃希菌、肺炎克雷伯菌对三、四代头孢菌素耐药率分别为59.8%和44.9%,耐碳青霉烯大肠埃希菌、肺炎克雷伯菌的检出率分别为2.7%和12.9%。鲍曼不动杆菌对亚胺培南、美罗培南的耐药率分别为73.7%和71.6%。结论辽宁地区血液中分离的病原菌存在不同程度耐药,应定期监测病原菌谱及耐药状况,为合理选用抗菌药物提供依据。Objective This article aims to explore pathogenic bacteria isolated from blood cultures and their drug resistance patterns in the Liaoning Province in 2019,which will improve understanding of the drug resistance of pathogens associated with bloodstream infections in this region.Methods The data of the strains isolated from the blood cultures was obtained from the Chinese Antimicrobial Resistance Monitoring System(CARSS)network in Liaoning Province between January 1 and December 31,2019.Strain identification and drug susceptibility testing were conducted as per the CARSS network guidelines.Whonet 5.6 software was used to analyze the data.Results A total of 6584 strains were isolated in 2019,of which 22.8%(1508 strains)were Gram-positive and 77.2%(5082 strains)were Gram-negative bacteria.The five most common isolates were Escherichia coli,Klebsiella pneumoniae,Staphylococcus aureus,Enterococcus faecium,and Acinetobacter baumannii.The MRSA isolation rate of Staphylococcus aureus was 18.4%.The resistance rates of Escherichia coli and Klebsiella pneumoniae to third and fourth generation cephalosporins were 59.8% and 44.9%,respectively.The detection rates of carbapenem-resistant Escherichia coli and Klebsiella pneumoniae were 2.7% and 12.9%,respectively,and the resistance rates of Acinetobacter baumannii to imipenem and meropenem were 73.7% and 71.6%,respectively.Conclusion The bacteria isolated from blood cultures in this area exhibit varying degrees of resistance to antibacterial drugs.The spectrum of pathogenic bacteria and their resistance patterns should be monitored regularly in this area to provide a basis to allow rational selection of antibacterial drugs.

关 键 词：细菌耐药监测 药物敏感率 甲氧西林耐药葡萄球菌 万古霉素耐药肠球菌 碳青霉烯耐药革兰氏阴性杆菌 

分 类 号：R378[医药卫生—病原生物学]