细胞膜受体蛋白的荧光成像与寡聚化调控研究进展  

Fluorescence imaging and oligomerization regulation of cell membrane receptor proteins

作　　者：黄梓芸 薛倩 邓翔熙 赵聪慧 孙芸琳 潘松兰 邹振 Huang Zi-yun;Xue Qian;Deng Xiang-xi;Zhao Cong-hui;Sun Yun-lin;Pan Song-lan;Zou Zhen(Hunan Provincial Key Laboratory of Cytochemistry,School of Chemistry and Food Engineering,Changsha University of Science&Technology,Changsha 410114,China)

机构地区：[1]长沙理工大学化学与食品工程学院,细胞化学湖南省重点实验室,湖南长沙410114

出　　处：《化学传感器》2020年第3期28-40,共13页Chemical Sensors

基　　金：国家自然科学基金(21705010,21735001,21605008);湖南省教育厅优秀青年项目(20B032)。

摘　　要：细胞膜受体作为真核细胞膜上一类重要的蛋白质,其在细胞通讯、增殖、迁移和周期以及众多人类生理和病理过程中起着至关重要的作用。近年来,一些能特异性识别细胞膜受体的分子探针已经被开发用于活细胞膜受体的成像和细胞内下游信号转导调节。该文主要介绍近年来细胞膜受体靶向监测成像策略与调控细胞膜受体寡聚化策略的发展。As an important protein on the eukaryotic cell membrane,cell membrane receptors play a vital role in cell communication,proliferation,migration and cycle,as well as many human physiological and pathological processes.In recent years,some molecular probes that can specifically recognize cell membrane receptors have been developed for the imaging of living cell membrane receptors and the regulation of downstream signal transduction in cells.This article mainly introduces the recent developments in the imaging strategy of cell membrane receptor targeted monitoring and the strategy of regulating cell membrane receptor oligomerization.

关 键 词：细胞膜受体 荧光 成像 受体寡聚化 调控 

分 类 号：O657.3[理学—分析化学] Q241[理学—化学]