中药厚朴及其成分厚朴酚与和厚朴酚体外抗各种球菌的药理作用研究进展  

Research Progress in Anti-coccus Effects of Magnoliae Officinalis Cortex,Magnolol and Honokiol on Various Coccus in vitro

作　　者：张明发[1] 沈雅琴[1] ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)

机构地区：[1]上海美优制药有限公司,上海201204

出　　处：《抗感染药学》2021年第9期1241-1244,共4页Anti-infection Pharmacy

摘　　要：中药厚朴不同溶剂的粗提取物具有体外抗各种球菌的药理作用,其中厚朴石油醚和乙醇提取物的抗球菌作用最强。厚朴酚(magnolol)及和厚朴酚(honokiol)是中药厚朴抗球菌的主要活性成分,其中厚朴酚抗球菌作用稍强于和厚朴酚。厚朴酚及和厚朴酚均能抑制金黄色葡萄球菌(以下简称"金葡菌")的自溶酶和α-溶血素、肠毒素-A、肠毒素-B的表达,阻断金葡菌的自溶和抑制其黏附功能及毒力,阻滞球菌诱导宿主细胞的炎性损伤反应。厚朴酚及和厚朴酚均能抑制被膜态金葡菌合成和释放eDNA和PIA,进而抑制生物被膜的形成,降低球菌的自我保护能力,产生抗球菌作用。本文中综述了中药厚朴及其成分厚朴酚及和厚朴酚体外抗各种球菌的药理作用,并对其研究进展做了分析。The crude extracts of Magnoliae Officinalis Cortex in different solvents have the pharmacological effects in vitro,among which petroleum ether and ethanol extracts have the strongest effects.Magnolol and honokiol are principal active components against coccus of Magnoliae Officinalis Cortex.The effect of magnolol seems stronger than honokiol.Magnolol and honokiol inhibit the expression of hemolytic enzyme,α-hemolysin,enterotoxin-A and enterotoxin-B in Staphylococcus aureus to block autolysis,and to decrease adhesiveness and virulence of Staphylococcus aureus,so blocking coccobacteria-induced inflammatory injury on host cell.Magnolol and honokiol inhibit Staphylococcus aureus of bacterial biofilm to synthesize and secrete eDNA and PIA,and to inhibit formation of bacterial biofilm,so decreasing self-protective ability of coccus to product effect of anti-coccus.In this paper,the pharmacological effects of magnolia officinalis and its components,magnolol and honokiol,against various coccus in vitro have been reviewed,and the research progress has been analyzed.

关 键 词：厚朴 厚朴酚 和厚朴酚 球菌 药理作用 

分 类 号：R961[医药卫生—药理学]