糖尿病患者皮下脂肪增生发生率的meta分析  

Incidence of lipohypertrophy of patients with diabetes: a meta-analysis

作　　者：李桂 李伟[2] 李君[3] 孙文秀[1] 于重燕[1] 曹立云[1] LI Gui;LI Wei;LI Jun;SUN Wenxiu;YU Chongyan;CAO Liyun(Department of Nephrology,Peking University First Hospital,Beijing 100034,P.R.China;General Practice Center,Peking University First Hospital,Beijing 100034,P.R.China;Department of Endocrinology,Peking University First Hospital,Beijing 100034,P.R.China)

机构地区：[1]北京大学第一医院肾内科,北京100034 [2]北京大学第一医院全科医学科,北京100034 [3]北京大学第一医院内分泌科,北京100034

出　　处：《华西医学》2021年第11期1578-1584,共7页West China Medical Journal

基　　金：北京大学第一医院科研基金资助课题(2017HL16)。

摘　　要：目的采用meta分析,探讨糖尿病患者皮下脂肪增生的发生率,为预防和减少其发生提供参考依据。方法计算机检索PubMed、Embase、Web of Science、中国知网、万方和维普数据库,并辅以文献追溯法和手工检索,检索建库至2021年9月有关糖尿病患者皮下脂肪增生的相关文献,由2名研究者独立进行文献筛选、资料提取和质量评价后,采用RevMan 5.4.1和R 3.3.1软件进行meta分析。结果最终纳入10篇文献,其中中文0篇,英文10篇,包括研究对象20 277例,糖尿病患者皮下脂肪增生的发生率为53%[95%置信区间(44%,62%)],纳入研究间的异质性较大(I2=99%,P<0.000 01)。单个协变量和多个协变量的meta回归分析发现发表年份、研究范围、研究地区、样本来源、研究中心、样本量可解释的异质性占51.6%。结论糖尿病患者皮下脂肪增生发生率高,亟待采取有效的干预措施来预防、诊断和治疗糖尿病患者的皮下脂肪增生问题。Objective To explore the incidence of lipohypertrophy in patients with diabetes by meta-analysis,and provide a reference for preventing and reducing its occurrence. Methods A computer search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure, Wangfang Data and Chongqing VIP databases, supplemented by literature retrospective method and manual search. Relevant documents related to lipohypertrophy in diabetic patients were searched until September 2021. After conducting independent literature screening, data extraction and quality evaluation, the researchers used RevMan 5.4.1 and R 3.3.1 softwares for metaanalysis. Results Ten articles were included, including 0 in Chinese and 10 in English, and 20 277 patients in total. The incidence of lipohypertrophy in patients with diabetes was 53% [95% confidence interval(44%, 62%)]. The heterogeneity among studies was statistically significant(I2=99%, P<0.000 01). Meta-regression analysis of single covariates and multiple covariates found that publication year, research scope, research area, sample source, research center, and sample size could explaine 51.6% of the heterogeneity. Conclusion The incidence of lipohypertrophy in patients with diabetes is high, and effective intervention measures are urgently needed to prevent, diagnose and treat the problem of lipohypertrophy in patients with diabetes.

关 键 词：糖尿病 皮下脂肪增生 META分析 

分 类 号：R587.2[医药卫生—内分泌]