致手足口病肠道病毒的病原学研究进展  

Research Progress on the Etiology of Enterovirus Causing Hand Foot and Mouth Disease

作　　者：黄浩[1] 盘珍梅 潘燕兰 HUANG Hao;PAN Zhenmei;PAN Yanlan(Wuzhou Municipality Center for Disease Control and Prevention,Wuzhou 543002,China)

机构地区：[1]梧州市疾病预防控制中心,梧州543002

出　　处：《病毒学报》2021年第6期1491-1501,共11页Chinese Journal of Virology

基　　金：广西壮族自治区梧州市科技研究计划,梧科字[2015]29。

摘　　要：手足口病是一种多病原体引起的儿童常见传染病,少数患者会进展为重症甚至死亡,对公共卫生造成巨大影响。目前国内虽已研制出EV71灭活疫苗并上市使用,对其它病毒所致手足口病并无交叉保护作用,并不能从总体上降低手足口病的发病率,在应对多种病原体的疫苗问世前,对手足口病病原体的基因进化监测、流行特征和病原学研究仍然是防控手足口病的重要措施。本文就手足口病在病原学方面的研究进展进行综述,为该病的科学防控提供有价值的信息。Hand foot and mouth disease(HFMD)is a common infectious disease in children caused by multiple pathogens. Certain patients will progress to severe or even death,which has a huge impact upon public health.At present,enterovirus(EV)71-inactivated vaccine has been developed and applied publicly in China. But there is no cross protective effect of this vaccine on cases caused by other pathogens,and it can not reduce the incidence of HFMD in general. Before vaccines against multiple pathogens are available,monitoring the genetic evolution of pathogens,epidemic characteristics and etiology research are still important strategies for prevention and control of HFMD. In this paper,the research progress on the etiology of Hand Foot and Mouth disease is reviewed,which should provide valuable information for the scientific prevention and control of the disease.

关 键 词：手足口病 肠道病毒 进化特征 受体 

分 类 号：R183.7[医药卫生—流行病学] R373.2[医药卫生—公共卫生与预防医学]