壳聚糖镓配合物的制备及抗菌性能研究  

Preparation of anovel chitosan-gallium complex as an antibacterial reagent

作　　者：付豪 万强 赵明源 戚晓宇 马红艳 FU Hao;WAN Qiang;ZHAO Mingyuan;QI Xiaoyu;MA Hongyan(School of Chemical Engineering and Materials, Tianjin University of Science and Technology,Tianjin 300457, China)

机构地区：[1]天津科技大学化工与材料学院,天津300457

出　　处：《功能材料》2021年第11期11177-11182,共6页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(21961132005);天津市自然科学基金资助项目(17JCYBJC22900)。

摘　　要：通过金属鳌合法制备了壳聚糖镓配合物,运用有机元素分析及电感耦合等离子发射光谱(ICP)法测定了C、H、O、N等元素比重,并运用粘度法、扫描电子显微镜(SEM)、傅里叶红外光谱分析(FTIR)、热失重分析(TGA)、X射线衍射(XRD)对壳聚糖镓配合物进行了表征,考察了壳聚糖镓配合物的抗菌性能。结果表明,在55℃水浴中鳌合制备的壳聚糖镓配合物(CS-Ga)对大肠杆菌与金黄色葡萄球菌的最低抑菌浓度分别为0.18和0.16 mg/mL;浓度为1.0 mg/mL的壳聚糖镓配合物在与细菌混合培养仅60 min后,即可完全抑制金黄色葡萄球菌的生长。A novel reagent of chitosan and gallium complex is prepared by metal chelation method.The content of C,H,O and N elements is measured by element analysis and inductively coupled plasma(ICP)emission spectroscopy.And the chitosan-gallium complex is characterized by viscosity method,scanning electron microscope(SEM),Fourier transform infrared spectroscopy(FTIR),thermogravimetric-differential thermal analysis(TG-DTA)and X ray diffraction(XRD).The antibacterial properties of chitosan-gallium complex against Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus)are also investigated.The results show that the minimum inhibitory concentrations against E.coli and S.aureus of chitosan-gallium complex(CS-Ga)prepared by chelating in 55℃water bath are 0.18 mg/mL and 0.16 mg/mL,respectively.The CS-Ga at a concentration of 1.0 mg/mL can completely inhibit the growth of S.aureus after only 60 min of mixed culture with bacteria.

关 键 词：壳聚糖 壳聚糖镓配合物 元素分析 抗菌性能 

分 类 号：O634.3[理学—高分子化学]