突发性耳聋患者高压氧治疗的有效性及对患者血浆PT、APTT、sVCAM-1、ICAM-1的影响  

Effectiveness of hyperbaric oxygen therapy for patients with sudden deafness and its effects on plasma PT,APTT,sVCAM-1,ICAM-1

作　　者：赵林[1] 徐亚谦 ZHAO Lin;XU Yaqian(Department of Hyperbaric Oxygen,Pinggu Hospital of Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing 101200,China)

机构地区：[1]首都医科大学附属北京友谊医院平谷医院高压氧科,北京市101200

出　　处：《河北医药》2021年第23期3621-3624,共4页Hebei Medical Journal

摘　　要：目的探讨突发性耳聋患者高压氧治疗的有效性及对患者血浆PT、APTT、sVCAM-1、ICAM-1的影响。方法选取2019年1~12月因突发性耳聋接收治疗的114例患者为研究对象,随机分为研究组与对照组。对照组采用常规西药治疗,研究组在对照组基础上联合高压氧治疗。比较2组临床效果,治疗前后凝血功能指标、血清相关因子治疗以及眩晕与耳鸣残存情况。结果与对照组比较,研究组总有效率显著较高,差异有统计学意义(P<0.05);与对照组治疗后比较,研究组PT及APTT指标均较高,差异有统计学意义(P<0.05);与对照组治疗后比较,研究组sVCAM-1与ICAM-1指标均较低,而VEGF水平明显较高,差异有统计学意义(P<0.05);与对照组比较,研究组眩晕及耳鸣残存率明显较低,差异有统计学意义(P<0.05)。结论对突发性耳聋患者采用高压氧治疗,其临床效果相对较高,患者血浆PT、APTT、sVCAM-1及ICAM-1水平均得到明显改善,眩晕及耳鸣残存率较低,安全、可靠,利于临床应用及推广。Objective To investigate the effectiveness of hyperbaric oxygen therapy for patients with sudden deafness and its effects on plasma PT,APTT,sVCAM-1,ICAM-1.Methods A total of 114 patients with sudden deafness who were treated in our hospital from January 2019 to December 2019 were enrolled in the study,who were randomly divided into control group and research group.The patients in control group were treated by conventional western medicine,however,the patients in research group,on the basis of control group,were given hyperbaric oxygen therapy.The clinical effects,and coagulation function indexes before and after treatment,serum related factors and the residual dizziness and tinnitus status were observed and compared between the two groups.Results The total effective rate in research group was significantly higher than that in control group(P<0.05),and the PT and APTT indexes in research group were superior to those in control group(P<0.05).After treatment,the levels sVCAM-1and ICAM-1 in research group were significantly lower than those in control group,however,the VEGF levels were significantly higher than those in control group(P<0.05).Moreover the residual rate of dizziness and the incidence of tinnitus in research group were significantly lower than those in control group(P<0.05).Conclusion The clinical effects of hyperbaric oxygen therapy for patients with sudden deafness are satisfactory,which can improve the plasma levels of PT,APTT,sVCAM-1 and ICAM-1,and the residual rate of vertigo and tinnitus of patients,therefor,it is worthy of clinical application and promotion.

关 键 词：突发性耳聋 高压氧治疗 临床疗效 凝血指标 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]