hs-CRP、PCT联合血清淀粉样蛋白A在HIV/AIDS合并感染中的表达及指导价值研究  

The expression of hs-CRP,PCT and serum amyloid A in patients with HIV/AIDS concurrent infection and its guidance value for clinical treatment

作　　者：陈华 黄婵娟[1] 李剑军 罗欢[1] CHEN Hua;HUANG Chanjuan;LI Jianjun(Department of Clinical Laboratory,Ruikang Hospital Affiliated to Guangxi TCM University,Guangxi,Nanning 530011,China;不详)

机构地区：[1]广西中医药大学附属瑞康医院检验科,南宁市530011 [2]广西壮族自治区疾病控制中心艾滋病防制所

出　　处：《河北医药》2021年第23期3628-3630,共3页Hebei Medical Journal

基　　金：国家自然科学基金项目(编号:81360442)。

摘　　要：目的探讨超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)联合血清淀粉样蛋白A(SAA)在人类免疫缺陷病毒感染者/艾滋病(HIV/AIDS)合并感染患者中的表达及临床治疗指导价值。方法选择2018年1月至2019年12月HIV/AIDS合并感染患者104例作为对象,设为观察组;选择同期治疗的HIV/AIDS患者98例,设为对照1组;均给予抗病毒/常规抗感染方法治疗;选择同期健康体检者57例,设为对照2组。比较hs-CRP、PCT及SAA在HIV/AIDS合并感染患者中的表达水平;绘制ROC曲线,分析hs-CRP、PCT及SAA在HIV/AIDS合并感染患者中的治疗指导效能。结果观察组HIV/AIDS合并感染患者hs-CRP、PCT及SAA水平高于对照1组和对照2组,差异有统计学意义(P<0.05);对照1组HIV/AIDS患者hs-CRP、PCT及SAA水平高于对照2组(P<0.05);观察组、对照1组治疗后12周hs-CRP、PCT及SAA水平均低于治疗前(P<0.05);观察组、对照1组治疗后12周hs-CRP、PCT及SAA水平差异无统计学意义(P>0.05);ROC曲线结果表明:hs-CRP、PCT及SAA在HIV/AIDS合并感染患者中诊断敏感性、特异性均高于单一hs-CRP、PCT及SAA(P<0.05)。结论hs-CRP、PCT及SAA在HIV/AIDS合并感染患者中表达异常,能反映患者疾病严重程度,加强三者联合测定能指导临床治疗,获得较高的敏感性、特异性。Objective To investigate the expression of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),and serum amyloid A(SAA)in patients with HIV/AIDS concurrent infection and its guidance value for clinical treatment.Methods A total of 104 patients with HIV/AIDS concurrent infection who were treated in our hospital from January 2018 to December 2019 were enrolled as observation group,at the same time,98 patients with HIV/AIDS were enrolled as control group 1,and the patients in both groups were given anti-virus/conventional anti-infection treatment,moreover,the other 57 healthy subjects were enrolled as control group 2.The expression levels of hs-CRP,PCT and SAA were observed and compared among groups.Moreover the ROC curve was plotted to analyze the significance of hs-CRP,PCT and SAA in treatment HIV/AIDS concurrent infection.Results The levels of hs-CRP,PCT and SAA in observation group were significantly higher than those in control group 1 and control group 2(P<0.05),moreover,which in control group 1 were significantly higher than those in control group 2(P<0.05).After 12-week treatment the levels of hs-CRP,PCT and SAA in observation group and the control group 1 were significantly decreased(P<0.05),however,there were no significant differences in the levels of hs-CRP,PCT,and SAA between observation group and control group 1(P>0.05).ROC curve results showed that hs-CRP,PCT,and SAA had higher diagnostic sensitivity and specificity in diagnosis of HIV/AIDS co-infected patients than those by single index(P<0.05).Conclusion The abnormal expression of hs-CRP,PCT and SAA exists in patients with HIV/AIDS concurrent infection,which can reflect the severity of the disease,and combined detection of the three indexes can guide clinical treatment and obtain higher sensitivity and specificity.

关 键 词：超敏C-反应蛋白 降钙素原 血清淀粉样蛋白A 人类免疫缺陷病毒感染者/艾滋病 合并感染 

分 类 号：R446.1[医药卫生—诊断学]