Mesenchymal stem cells are more effective than captopril in reverting cisplatin-induced nephropathy  

作　　者：ENTSAR A.SAAD REDA S.EL-DEMERDASH EMAN M.ABD EI-FATTAH 

机构地区：[1]Chemistry Department,Faculty of Science,Damietta University,Damietta,Egypt [2]Urology&Nephrology Center,Faculty of Medicine,Mansoura University,Egypt

出　　处：《BIOCELL》2019年第2期73-79,共7页生物细胞（英文）

摘　　要：Cisplatin is a powerful anticancer drug but its nephrotoxic effects limit its clinical use.We aimed to evaluate the effect of mesenchymal stem cells(MSCs)injection or of captopril to counteract the cisplatin-induction of nephropathy.MSCs isolation,preparation and tracking,transforming growth factor-β(TGF-β)and interleukin-10(IL-10)expressions,kidney function tests,oxidative stress state,and histological examinations were done.Cisplatin-induced nephropathy was indicated biochemically and confirmed histopathologically.MSCs treatment showed normal kidney architecture and significantly decreased oxidative stress and TGF-β while increased IL-10 and improved kidney function tests.Rats treated with cisplatin+captopril showed noticeable kidney histopathological changes.Superior positive impact of MSCs in amelioration of cisplatin-induced nephropathy via their ability to motivate functional and structural renal repair is evidenced.

关 键 词：HISTOPATHOLOGY IL-10 MINERALS NEPHROPATHY Oxidative stress PCR Repair TGF-β 

分 类 号：R69[医药卫生—泌尿科学]