雄激素调控男性性唤起作用机制的研究进展  

The role of androgen in male sexual arousal

作　　者：高鑫涛 刘夏铭(综述) 丁凤菲 刘继红(审校)[1] GAO Xin-tao;LIU Xia-ming;DING Feng-fei;LIU Ji-hong(Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;School of Basic Medical Sciences,Shanghai Medical College,Fudan University,Shanghai 200433,China)

机构地区：[1]华中科技大学同济医学院附属同济医院泌尿外科,湖北武汉430030 [2]复旦大学上海医学院基础医学院,上海200433

出　　处：《中华男科学杂志》2021年第9期833-839,共7页National Journal of Andrology

基　　金：国家自然科学基金面上项目(82072838)。

摘　　要：性唤起是性行为能否成功的重要因素,接受中枢神经系统的调控,其中的机制较为复杂且尚不明确。雄激素是男性最重要的内分泌激素,深入参与了男性性反应的每个步骤,但它具体如何调控男性性唤起目前仍未被完全阐明,仍是当前男科研究的热点之一。因此本文全面综述了雄激素在男性性唤起中的相关作用及机制的研究进展。在中枢神经系统中,雄激素可通过结合雄激素受体或代谢为神经类固醇影响多巴胺神经递质的释放,从而调控大脑奖赏系统的激活。另一方面,雄激素可通过调控性唤起神经环路中神经元可塑性和棘突的形成保证性唤起神经环路的成功激活和传导。然而,性唤起的具体调控机制仍有待深入研究。Sexual arousal is an important factor for the success of sexual behavior,and regulated by the central nervous system,its underlying mechanism is very complicated.Androgen is the most important endocrine hormone in men,which is deeply involved in the whole process of male sexual response,but how it regulates male sexual arousal has not been fully clarified and remains one of the hotspots in current andrological research.Therefore,this paper presents an overview of the advances in the studies of the related role and mechanism of androgen in male sexual arousal.In the central nervous system,androgen regulates the release of dopamine neurotransmitters by binding androgen receptors or metabolizing neurosteroids,thus activating the brain reward system.Besides,androgen regulates the neuronal plasticity and spinous process formation in the neural circuit of sexual arousal to ensure successful activation and conduction of the neural circuit.However,the specific regulating mechanism of sexual arousal remains to be further explored.

关 键 词：男性 性唤起 雄激素 雄激素受体 多巴胺 

分 类 号：R698[医药卫生—泌尿科学]