冠状病毒与宿主细胞骨架相互作用的研究进展  

Interaction between coronavirus and host cytoskeleton:a review

作　　者：王洁茹 戴银[1] 沈学怀[1] 尹磊 周学利[1] 潘孝成[1] WANG Jie-ru;DAI Yin;SHEN Xue-huai;YIN Lei;ZHOU Xue-li;PAN Xiao-cheng(Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering,Livestock and Poultry Epidemic Diseases Research Center of Anhui Province,Institute of Animal Husbandry and Veterinary Science,Anhui Academy of Agricultural Science,Hefei 230031,China)

机构地区：[1]安徽省农业科学院,畜牧兽医研究所,安徽省畜禽疫病研究中心,畜禽产品安全工程安徽省重点实验室,安徽合肥230031

出　　处：《中国兽医科学》2021年第11期1433-1437,共5页Chinese Veterinary Science

基　　金：安徽省自然科学基金项目(2008085QC138);安徽省科技重大专项项目(202003a06020012);安徽省畜禽疫病研究中心项目(2021YL065)。

摘　　要：冠状病毒是所有RNA病毒中基因组最大的正链RNA病毒,仅感染脊椎动物,与多种动物和人类的疫病有关。在冠状病毒入侵、细胞内复制、组装、运输及出芽释放过程中,宿主细胞骨架与冠状病毒密切接触。本文对冠状病毒诱导或劫持的细胞骨架结构(包括肌动蛋白、微管和中间纤维)机制作简要概述,为进一步深入研究细胞骨架在病毒感染中的作用机制提供参考。Coronavirus is a positive-strand RNA virus with the largest genome among all RNA viruses and can affect a wide range of vertebrate in connection,as well as human.Host cell cytoskeletons have been reported to involved in the process of virus entry,intracellular replication transport,assembly and egress of coronavirus,although many detailed mechanisms are still unclear.This article provides a brief overview of the function of the most prominent coronavirus-induced or-hijacked cytoskeletal structures including actin,microtubules and intermediate filaments.This article will provide evidence for future research on the interaction between the coronavirus and the host cytoskeleton.

关 键 词：冠状病毒 细胞骨架 微丝 微管 中间纤维 

分 类 号：S852.6596[农业科学—基础兽医学]