分化抑制因子在免疫细胞发育及血液恶性肿瘤发生中的调控作用  

Diverse Roles of Inhibitor of Differentiation in Immune Cell Development and Hematologic Malignancies

作　　者：石金凤 李庆伟[1,2,3] 王浩 SHI Jin-Feng;LI Qing-Wei;WANG Hao(Department of Biological Science,School of Life Sciences,Liaoning Normal University;Lamprey Research Center,Liaoning Normal University;Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116081,Liaoning,China)

机构地区：[1]辽宁师范大学生命科学学院生物科学系 [2]辽宁师范大学七鳃鳗研究中心 [3]大连工业大学海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116081

出　　处：《中国生物化学与分子生物学报》2021年第11期1458-1465,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31601150);中国博士后科学基金(No.2016M601329)资助。

摘　　要：分化抑制因子(inhibitor of differentiation,Id)属于螺旋-环-螺旋蛋白家族成员,通过与其他HLH蛋白质形成异源二聚体而发挥转录负调控作用,抑制基因的表达。Id可促进细胞的增殖,抑制细胞分化。尤其在多种免疫细胞的发育和分化过程中,Id发挥着必不可少的作用。本篇综述主要介绍了近年来关于Id家族各成员在先天性和适应性免疫系统中如何调控多种细胞谱系的产生及命运决定的最新研究进展。Id通过与E蛋白等不同的转录因子相互作用,在自然杀伤细胞、先天性淋巴细胞、T细胞和B细胞等的分化过程中具有多种多样的功能,确保了免疫细胞在各免疫器官中发育的有序进行。另一方面,Id基因的异常表达及功能失衡与血液系统恶性肿瘤的发生和进展程度密切相关。在从白血病到恶性淋巴瘤的不同血液肿瘤中,Id可作为促癌或抑癌因子发挥多样的作用。因此,Id可作为血液肿瘤诊断及预后的标记基因,并有望成为肿瘤治疗的重要靶标。Inhibitor of differentiation(Id)is a member of the helix-loop-helix protein family and exerts negative transcriptional regulation by forming heterodimers with other HLH proteins to inhibit gene expression.Id can promote cell proliferation and inhibit cell differentiation.Especially,Id plays an essential role in the development and differentiation of various immune cells.This review mainly introduces the latest research progress in how members of the Id family regulate the generation and fate determination of multiple cell lineages in the innate and adaptive immune systems.By interacting with different transcription factors such as E protein,Id has a variety of functions in the differentiation process of natural killer cells,innate lymphoid cells,T cells,and B cells,etc.,ensuring the well-coordinated development of immune cells in various immune organs.On the other hand,the abnormal expression and functional deficiency of the Id gene are closely related to the occurrence and progression of hematologic malignancies.In different hematologic malignancies ranging from leukemia to malignant lymphoma,Id plays diverse roles as a cancer-promoting or tumor suppressor factor.Therefore,Id can be used as a marker for the diagnosis and prognosis of hematologic malignancies and has the potential to become an important target for cancer therapy.

关 键 词：分化抑制因子 免疫系统 细胞分化 血液系统恶性肿瘤 

分 类 号：Q74[生物学—分子生物学] Q279