艰难梭菌与抗生素相关腹泻的研究进展  

Advances in Clostridium difficile and antibiotic-associated diarrhea

作　　者：朱佳源 谭周进[1] 郑淘[1,2] 肖嫩群 ZHU Jia-yuan;TAN Zhou-jin;ZHENG Tao;XIAO Nen-qun(Hunan University of Chinese Medicine,Changsha 410208,China;Department of Food and Drug Engineering,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学药学院食品药品工程系,湖南长沙410208

出　　处：《中国感染控制杂志》2021年第12期1168-1173,共6页Chinese Journal of Infection Control

基　　金：湖南省自然科学基金(2020JJ4468);湖南中医药大学生物工程重点学科资助(校行科字[2018]3号)。

摘　　要：抗生素相关性腹泻(AAD)是指应用抗生素后发生的、与抗生素有关的腹泻,是常见的药物不良反应,其发病机制并未完全阐明。艰难梭菌(CD)是一种具有芽孢结构厌氧的肠道致病菌,被认为是引起AAD的常见原因,越来越多研究表明AAD与艰难梭菌感染(CDI)相关,但CD致AAD的作用机制尚不十分明确。本文通过阐明AAD与CD的关系,并从多个方面分析CD致AAD可能作用机制以及目前存在的一些相关治疗方法,以期改进AAD的治疗与预防。Antibiotic-associated diarrhea(AAD)refers to the diarrhea related to antibiotics after the application of antibiotics,it is a common adverse drug reaction,and its pathogenesis has not been fully elucidated.Clostridium difficile(CD)is an anaerobic enteropathogen with spore structure,which is considered to be a common cause of AAD,more and more studies have shown that AAD is related to CD infection(CDI),but the mechanism of CD-induced AAD is not very clear.This paper elucidates the relationship between AAD and CD,analyzes the possible mechanism of CD-induced AAD and some currently existing treatment methods from multiple aspects,so as to improve the treatment and prevention of AAD.

关 键 词：艰难梭菌 抗生素相关腹泻 作用机制 治疗方法 

分 类 号：R181.32[医药卫生—流行病学] R516[医药卫生—公共卫生与预防医学]