鲍曼不动杆菌的调控性非编码RNA与抗菌药物耐药  

Regulatory non-coding RNAs and antimicrobial resistance of Acinetobacter baumannii

作　　者：彭勤 凌保东[1,2] PENG Qin;LING Bao-dong(Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs,Chengdu Medical College,Chengdu 610500,China;School of Pharmacy,Chengdu Medical College,Chengdu 610500,China;Department of Pharmacy,Nanchong Central Hospital,Nanchong 637000,China)

机构地区：[1]成都医学院结构特异性小分子药物研究四川省高校重点实验室,四川成都610500 [2]成都医学院药学院,四川成都610500 [3]南充市中心医院药学部,四川南充637000

出　　处：《中国感染控制杂志》2021年第12期1174-1178,共5页Chinese Journal of Infection Control

基　　金：国家自然科学基金委项目(81373454)。

摘　　要：鲍曼不动杆菌是医院感染常见病原菌之一。多重耐药菌,甚至全耐药菌的出现给世界公共卫生安全带来极大的威胁。近年来,多项试验研究证明,细菌可在抗菌药物等压力条件下通过产生特异性的ncRNAs或通过其构像的变化调控相关耐药基因的表达,在调节细菌的耐药性等方面起着重要作用。总结调控性非编码RNAs对鲍曼不动杆菌耐药性的调控作用及其作为药物靶点的研究,以期为应对鲍曼不动杆菌耐药问题提供帮助。Acinetobacter baumannii is one of the common pathogens causing healthcare-associated infection,the emergence of multidrug-resistant organisms,even pandrug-resistant organisms,poses a great threat to the world public health security.In recent years,a number of experimental studies have proved that bacteria can regulate the expression of relevant antimicrobial resistance genes by generating specific non-coding RNAs(ncRNAs)or changing their conformation under the pressure of antimicrobial agents,and play an important role in regulating antimicrobial resistance of bacteria.This review summarizes the research on regulatory role of regulatory ncRNAs on antimicro-bial resistance of Acinetobacter baumannii and ncRNAs as drug targets,in order to provide help to deal with the problem of antimicrobial resistance of Acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 调控性非编码RNAs 耐药性 药物靶点 

分 类 号：R378[医药卫生—病原生物学]