AIDS患者肝损伤的外周血指标相关性分析  

Correlation Analysis of Peripherally Hematic Factors among AIDS Patients with Liver Damage

作　　者：贺铮铮[1] 孙俊[1] 王莉[1] 杨玉琪[1] He Zhengzheng;Sun Jun;Wang Li;Yang Yuqi(Yunnan Institute of Traditional Chinese Medicine and Materia Medica,Kunming 650223,China)

机构地区：[1]云南省中医中药研究院,昆明650223

出　　处：《大理大学学报》2021年第10期67-71,共5页Journal of Dali University

基　　金：云南省医疗卫生单位内设研究机构科研项目(2016NS337);云南省科技惠民专项项目(2013CA020)。

摘　　要：目的:探讨获得性免疫缺陷综合征(AIDS)患者丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)与外周血指标的相关性,为提高AIDS肝功能受损患者的临床疗效提供参考。方法:选取云南省中医药治疗艾滋病试点项目数据库中2968例中医药治疗前的AIDS患者,其中ALT异常者816例,AST异常者777例,收集患者的一般临床资料和实验室检查资料,采用Logistic回归分析法分析肝损伤相关因素。结果:AIDS患者肝功能受损与血红蛋白(Hb)、血小板(PLT)、CD4^(+)T淋巴细胞变化存在显著相关性,Logistic回归分析显示,患者ALT、AST水平与Hb呈正相关(P<0.05),与PLT、CD4^(+)T淋巴细胞呈负相关(P<0.05)。结论:云南省肝功能受损的AIDS患者,ALT、AST水平与Hb、PLT、CD4^(+)T淋巴细胞水平密切相关。Objective:To investigate the correlation between alanine aminotransferase(ALT),aspartate aminotransferase(AST)and peripherally hematic factors in AIDS patients in order to provide guidance for better treatment of liver damage.Methods:2968 AIDS patients from database of a pilot project named Traditional Chinese Medicine Treatment for HIV in Yunnan,including 816 patients with abnormal ALT and 777 with abnormal AST,were enrolled in this study.General clinical information and measures of laboratory test were collected.Logistic regression analysis was performed to explore the factors related to liver damage.Results:The liver damage was significantly correlated with alterations of Hb,PLT and CD4^(+)T lymphocytes.Logistic regression analysis showed that the levels of ALT and AST were positively correlated with Hb(P<0.05),whereas negatively correlated with PLT and CD4^(+)T lymphocytes.Conclusion:In AIDS patients with impaired liver function in Yunnan Province,the levels of ALT and AST are closely related to the levels of Hb,PLT,and CD4^(+)T lymphocytes.

关 键 词：获得性免疫缺陷综合征 肝功能 影响因素 LOGISTIC回归分析 

分 类 号：R512.91[医药卫生—内科学]