姜黄汤剂在治疗寻常型银屑病中的辅助价值及其对血清IL-22水平的影响  

Value of Turmeric Decoction in Adjuvant Treatment of Psoriasis Vulgaris and Its Effect on Serum IL-22 Level

作　　者：贾红侠[1] 何焱玲[1] 兰东[1] 问明亚[1] JIA Hong-xia;HE Yan-ling;LAN Dong;WEN Ming-ya(Department of Dermatology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院皮肤科,北京100020

出　　处：《中国美容医学》2021年第11期107-110,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨姜黄汤剂对寻常型银屑病的辅助治疗价值及其对血清白细胞介素-22(IL-22)水平的影响。方法:选取2019年7月-2020年9月笔者医院收治的114例寻常型银屑病患者为研究对象,采用随机数字表法分为对照组(57例)和研究组(57例)。对照组采用卤米松、卡泊三醇治疗,研究组在对照组的基础上另给予姜黄汤剂治疗,两组均持续治疗10周后观察效果。对比两组治疗前后银屑病严重程度指数(PASI)评分及疗效,统计两组治疗前后血清IL-22水平及皮肤生理指标情况,比较两组药物安全性。结果:治疗前,两组PASI评分比较差异均无统计学意义(P>0.05);治疗后,两组PASI评分相较于治疗前均降低(P<0.05),且研究组治疗后PASI评分低于对照组(P<0.05),研究组总有效率高于对照组(P<0.05);治疗前,两组IL-22水平对比差异均无统计学意义(P>0.05),治疗后,两组IL-22水平相较于治疗前均降低(P<0.05),且研究组治疗后IL-22水平低于对照组(P<0.05);治疗前,两组角质层含水量、皮肤油脂水平对比差异均无统计学意义(P>0.05),治疗后,两组角质层含水量、皮肤油脂水平相较治疗前均提高(P<0.05),且研究组角质层含水量、皮肤油脂水平均高于对照组(P<0.05)。两组总不良反应发生率对比差异无统计学意义(P>0.05)。结论:姜黄汤剂辅助治疗寻常型银屑病可明显减轻病情,疗效显著,降低血清IL-22水平,促进皮肤屏障恢复,且安全性良好。Objective To explore the value of turmeric decoction in adjuvant treatment of psoriasis vulgaris and its effect on serum interleukin-22(IL-22) levels. Methods 114 patients with psoriasis vulgaris admitted to our hospital from July 2019 to September 2020 were selected as the research subjects. They were divided into control group(57 cases) and study group(57 cases) using random number table method. The control group was treated with halometasone and calcipotriol, and the study group was treated with turmeric decoction on the basis of the control group. Both groups were treated for 10 weeks and the effect was observed. The Psoriasis Severity Index(PASI) scores and efficacy of the two groups were compared before and after treatment. The serum IL-22 levels and skin physiological indicators of the two groups before and after treatment were counted.The safety of the two groups of drugs was compared. Results There was no significant difference in the comparison of PASI scores between the two groups before treatment(P>0.05). The PASI scores of the two groups after treatment were lower than before treatment(P<0.05), and the PASI scores of the study group were lower than control group after treatment(P<0.05).The total effective rate of the study group was higher than control group(P<0.05). There was no statistically significant difference in the levels of IL-22 between the two groups before treatment(P>0.05). The levels of IL-22 in the two groups after treatment were lower than before treatment(P<0.05), and the level ofIL-22 in the study group after treatment was lower than control group(P<0.05). There was no significant difference in water content of the stratum corneum and skin oil levels between the two groups before treatment(P>0.05). The water content of the stratum corneum and skin oil levels of the two groups after treatment increased comparing with before treatment(P<0.05). The water content of the stratum corneum and the skin oil level of the study group after treatment were higher than control group(P<0.05). Ther

关 键 词：姜黄汤剂 常型银屑病 疗效 白细胞介素-22 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]