外泌体在组织修复及抗瘢痕治疗中的研究进展  

Advance in Research on Exosomes in Tissue Repair and Anti-scarring Treating

作　　者：史敏[1] 毕芳芳 张明雨 陈炜荧(综述) 丁欣强(审校)[2] SHI Min;BI Fang-fang;ZHANG Ming-yu;CHEN Wei-ying;DING Xin-qiang(Xi’an Peihua University,Xi’an 710125,Shaanxi,China;Department of Dermatology,Xi'an Children's Hospital,Xi’an 710003,Shaanxi,China)

机构地区：[1]西安培华学院,陕西西安710125 [2]西安市儿童医院皮肤科,陕西西安710003

出　　处：《中国美容医学》2021年第11期179-182,共4页Chinese Journal of Aesthetic Medicine

基　　金：2020年度西安培华学院校级科研项目自然科学研究计划(名称:Mir-506-3p/Beclin-1对烧伤后皮肤成纤维细胞自噬与增殖调节作用的研究,编号:PHKT2036)。

摘　　要：促进皮肤创面愈合、减少瘢痕形成是皮肤科及整形外科的治疗重心。近年来研究发现,外泌体(EXOs)作为细胞与细胞之间的通信工具参与了旁分泌作用,并被发现在多种病理生理过程及疾病进程中发挥着重要作用,逐渐成为肿瘤免疫领域及再生医学领域研究的热点。外泌体可促进创面修复,通过抑制早期炎症反应、促进血管生成和细胞增殖、调控胶原重塑来抑制瘢痕形成,为皮肤创面修复提供了一个全新的促愈合方法。外泌体在创面修复及抗瘢痕治疗中具有广阔的应用前景,有望为创伤修复及抗瘢痕治疗开拓新路径。It is always the focus of treatment in dermatology and plastic surgery, such as promoting skin wound healing and reducing scar formation. In recent years, it was found that exosomes(EXOs), as a communication tool between cells, participate in paracrine functions, and have been found to play an important role in a variety of pathophysiological processes and disease processes, and have gradually become the field of tumor immunity and research hotspots in the field of regenerative medicine.Exosomes can promote wound healing,inhibit scar formation by inhibiting early inflammation,promoting angiogenesis and cell proliferation, and regulating collagen remodeling, thereby providing a new method of promoting healing for skin wound.Exosomes have broad application prospects in wound healing and anti-scarring effects, and they are expected to open up innovative ways for wound healing and anti-scar treatment.

关 键 词：外泌体 瘢痕 创面修复 成纤维细胞 细胞外基质 

分 类 号：R619.6[医药卫生—外科学]