合并2型糖尿病的乳腺癌患者临床病理特征及预后分析  

Clinicopathological Features and Prognosis of Breast Cancer Patients with Type 2 Diabetes Mellitus

作　　者：汤晓晖[1] 陈祥[2] TANG Xiaohui;CHEN Xiang(Department of Pathology,Longyan Second Hospital,Longyan 364000,China;Department of Breast Surgery,Longyan Second Hospital,Longyan 364000,China)

机构地区：[1]福建省龙岩市第二医院病理科,福建龙岩364000 [2]福建省龙岩市第二医院乳腺外科,福建龙岩364000

出　　处：《中国医药指南》2021年第33期22-24,共3页Guide of China Medicine

摘　　要：目的分析合并2型糖尿病的乳腺癌患者临床病理特征及预后效果。方法病例收集时间为2019年1月至2020年7月,选择来我院就诊的120例原发性乳腺癌患者为观察对象,其中将合并2型糖尿病的乳腺癌患者(50例)设为观察组,将非糖尿病的乳腺癌患者(70例)设为对照组,对比两组患者的临床病理学特征以及预后效果。结果两组患者的临床一般资料对比,观察组患者的年龄、绝经后患者比例以及体质量指数(BMI)均明显高于对照组,差异有统计学意义(P<0.05);观察组患者的乳腺肿瘤直径大于对照组,两组肿瘤分期、腋窝淋巴结阳性率、雌激素受体(ER)阴性率、血糖、血脂、C反应蛋白(CRP)、血清胱抑素C(Cys-C)与对照组相比,差异有统计意义(P<0.05);观察组患者的复发转移概率、并发症发生率高于对照组,住院时间、下床活动时间短于对照组,引流量多于对照组,差异有统计学意义(P<0.05)。结论糖尿病是乳腺癌的高危因素,其预后效果差,病理分期晚,血糖水平高,肿瘤转移风险高,生存率较低,因此要予以患者个体化治疗,重视术后随访和定期复查。Objective To analyze and evaluate the clinicopathological features and prognosis of breast cancer patients with type 2 diabetes mellitus.Methods The cases were collected from January 2019 to July 2020,120 patients with primary breast cancer were selected as the observation subjects.Among them,2 patients with type 2 diabetes mellitus(50 cases)were selected as the observation group.The patients with non-diabetic breast cancer(70 cases)were allocated as the control group.The clinicopathological characteristics and prognosis of the two groups were compared and analyzed.Results The age,proportion of postmenopausal patients and body mass index(BMI)in the observation group were significantly higher than those in the control group(P<0.05).The diameter of breast tumor in the observation group was larger than that in the control group.There were significant differences in tumor stage,positive rate of axillary lymph nodes,negative rate of estrogen receptor(ER),blood glucose,blood lipid,C-reactive protein(CRP),serum cystatin C(Cys-C)between the two groups(P<0.05).The recurrence and metastasis probability and complication rate in the observation group were higher than those in the control group(P<0.05).The length of hospital stay,out of bed activity time and drainage volume were more than those in the control group(P<0.05).Conclusion Diabetes is a high risk factor for breast cancer.Its prognosis is poor,its pathological stage is late,its blood sugar level is high,its metastasis risk is high,and its survival rate is low.Therefore,individualized treatment should be given to patients,and postoperative follow-up and regular review should be emphasized.

关 键 词：2型糖尿病 乳腺癌 临床病理特征 预后效果 

分 类 号：R587.2[医药卫生—内分泌] R737.9[医药卫生—内科学]