唑来膦酸联合骨化三醇对骨质疏松症患者骨密度及骨代谢相关指标的影响  

Effect of Zoledronic Acid Combined with Calcitriol on Bone Mineral Density and Bone Metabolism in Patients with Osteoporosis

作　　者：朱道信[1] 罗志环[1] 陈少健[1] 杨康骅[1] ZHU Dao-xin;LUO Zhi-huan;CHEN Shao-jian;YANG Kang-hua(Department of Sports Medicine,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市人民医院运动医学科,江西赣州341000

出　　处：《医学信息》2021年第23期162-164,共3页Journal of Medical Information

摘　　要：目的研究唑来膦酸联合骨化三醇对骨质疏松症患者骨密度及骨代谢相关指标的影响。方法选取2020年6月-2021年6月我院收治的82例骨质疏松症患者,依据随机数字表法分为对照组和观察组,每组41例。对照组给予骨化三醇治疗,观察组在对照组基础上联合唑来膦酸治疗,比较两组骨密度(腰椎、股骨颈、髋部)、骨代谢相关指标[血清骨钙素(BGP)、总1型前胶原氨基端延长肽(总P1NP)、β-胶原特殊序列(β-CTX)]、疼痛模拟视觉评分量表(VAS)及不良反应发生情况。结果观察组腰椎、股骨颈、髋部骨密度高于对照组,差异有统计学意义(P<0.05);观察组BGP、总P1NP、β-CTX水平及VAS评分低于对照组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论唑来膦酸联合骨化三醇可增加骨质疏松症患者骨密度,下调骨代谢指标,改善疼痛症状,且不增加不良反应发生风险。Objective To study the effect of zoledronic acid combined with calcitriol on bone mineral density and bone metabolism related indexes in patients with osteoporosis.Methods A total of 82 patients with osteoporosis admitted to our hospital from June 2020 to June 2021 were randomly divided into control group and observation group,with 41 cases in each group.The control group was treated with calcitriol,and the observation group was treated with zoledronic acid on the basis of the control group.The bone mineral density(lumbar spine,femoral neck,hip),bone metabolism-related indicators[serum osteocalcin(BGP),total N-terminal propeptide of type 1 procollagen(total P1NP),β-crosslaps(β-CTX)],pain simulation visual score(VAS)and adverse reactions were compared between the two groups.Results The bone mineral density of lumbar spine,femoral neck and hip in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).BGP,total P1NP,β-CTX levels and VAS scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Zoledronic acid combined with calcitriol can increase bone mineral density in patients with osteoporosis,reduce bone metabolism indexes,improve pain symptoms,and do not increase the risk of adverse reactions.

关 键 词：骨质疏松症 骨化三醇 唑来膦酸 骨密度 骨代谢 

分 类 号：R580[医药卫生—内分泌]