生物样本中司来吉兰及其代谢物R(-)-甲基苯丙胺的研究进展  

Research Progress of Selegiline and Its Metabolite R-methamphetamine in Biological Samples

作　　者：于哲 任昕昕[2] 王爱华[2] 邸玉敏[3] 邹波 王瑞花[2] 张云峰[2] 常靖[2] 于忠山[2] YU Zhe;REN Xinxin;WANG Aihua;DI Yumin;ZOU Bo;WANG Ruihua;ZHANG Yunfeng;CHANG Jing;YU Zhongshan(People’s Pubilc Security University of China,Beijing 100038,China;Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China;Drug Control Detachment,Tianjin Public Security Bureau,Tianjin 300240,China)

机构地区：[1]中国人民公安大学,北京100038 [2]公安部物证鉴定中心,北京100038 [3]天津市公安局禁毒支队,天津300240

出　　处：《刑事技术》2021年第6期629-634,共6页Forensic Science and Technology

基　　金：中央级公益性科研院所基本科研业务费专项资金项目(2017JB008)。

摘　　要：司来吉兰是一种治疗帕金森综合征的药物,在体内可代谢为甲基苯丙胺。近年来有不少非法吸毒者在血液、尿液中检出甲基苯丙胺后辩称其服用司来吉兰治疗疾病,属正常用药,企图逃避法律制裁。由于司来吉兰及其代谢物具有左旋手性结构,因此可以成为辨别甲基苯丙胺滥用和司来吉兰正常服用的标志。相关检测手段主要有气相色谱法、液相色谱法与质谱的串联,生物检材包括血液、尿液、头发、唾液以及干斑点。本文综述了司来吉兰在体内的作用机制、代谢物(去甲司来吉兰、R(-)-甲基苯丙胺、R(-)-苯丙胺等)、分析检测技术等研究进展,以供法庭科学毒物分析工作者借鉴。Selegiline,a drug for treatment of Parkinson’s syndrome,can metabolize into methamphetamine in vivo.With the effectual functions to inhibit the activity of monoamine oxidase and increase the concentration of dopamine,selegiline plays its role into alleviating Parkinson’s symptoms of the involved patients.Commonly,selegiline will metabolize into R(-)methamphetamine,R(-)-amphetamine,desmethylselegiline and other substances alike in vivo.Both selegiline and its metabolites have a left-handed chiral structure such a reliable sign that can be utilized to detect whether some methamphetamine is abused or derived from official administration of selegiline.This article reviews the research progress of selegiline about its functional mechanism,metabolites and detection methods for forensic toxicology.Determination of selegiline usually carries out with gas chromatography,liquid chromatography and related techniques.Actually,there have been forensic actual cases that adopted relevant testing methods to determine whether they were of normal selegiline usage or abusing methamphetamine.Besides,selegiline and metabolites are also able to play their role into estimating the use of illicit drugs in cities(or certain areas),capable of determining whether methamphetamine is abused or from the various metabolites of selegiline.The future forensic toxicological researches and identification should pay attentions to the discrepancy,to the influence of other biological materials on test results,and to exploration into available detection techniques about selegiline quantitative analysis.

关 键 词：法医毒理学 司来吉兰 甲基苯丙胺 生物样本 体内代谢 

分 类 号：D795.1[政治法律—政治学]