氟比洛芬酯辅助舒芬太尼对老年宫颈癌患者术后早期认知功能障碍发生率的影响  

Effect of flurbiprofen axetil assisted sufentanil on the incidence of early postoperative cognitive dysfunction in elderly patients with cervical cancer

作　　者：董天鑫[1] 高树强 张云鹏 李艳[1] 张德利[1] DONG Tianxin;GAO Shuqiang;ZHANG Yunpeng;LI Yan;ZHANG Deli(Department of Anesthesiology,Affiliated Hospital of Chengde Medical College,Chengde 067000,Hebei,China)

机构地区：[1]承德医学院附属医院麻醉科,河北承德067000

出　　处：《中国性科学》2021年第11期60-63,共4页Chinese Journal of Human Sexuality

基　　金：承德市科学技术研究与发展计划项目(201804A032)。

摘　　要：目的探讨氟比洛芬酯辅助舒芬太尼对老年宫颈癌患者术后早期认知功能障碍(POCD)发生率的影响。方法选取2019年3月至2020年12月承德医学院附属医院诊治的74例老年宫颈癌患者作为研究对象。采用随机数字表法分为观察组(采用氟比洛芬酯联合舒芬太尼镇痛)和对照组(采用舒芬太尼镇痛组),每组37例。比较两组视觉模拟评分法(VAS)、简易智力状态检查量表(MMSE)、Ramsay镇静评分、术后静脉自控镇痛(PCIA)情况及血清S-100β蛋白、白细胞介素6(IL-6)、白细胞介素10(IL-10)、肿瘤坏死因子α(TNF-α)变化情况、POCD发生率。结果术后4h、12h、24h、48h,观察组VAS、Ramsay评分低于对照组,差异具有统计学意义(P<0.05);术后1h、24h,观察组自控按压次数、舒芬太尼用量均低于对照组,差异具有统计学意义(P<0.05);术后1d、3d、5d,观察组MMSE评分、POCD发生率低于对照组,差异具有统计学意义(P<0.05);术后1d、3d、5d,两组IL-6、IL-10、TNF-α、S-100β均呈下降趋势,且观察组各指标均低于对照组,差异具有统计学意义(P<0.05)。结论氟比洛芬酯辅助舒芬太尼应用于老年宫颈癌患者术后,能减轻患者术后早期POCD损伤。Objective To investigate the effect of flurbiprofen axetil assisted sufentanil on the incidence of early postoperative cognitive dysfunction(POCD) in elderly patients with cervical cancer. Methods 74 elderly patients with cervical cancer treated in the Affiliated Hospital of Chengde Medical College from March 2019 to December 2020 were selected and divided into observation group(flurbiprofen ester combined with sufentanil for analgesia) and control group(sufentanil for analgesia) by random number table method, with 37 patients in each group. Visual analog scale(VAS), mini-mental state examination(MMSE), Ramsay sedation score, postoperative controlled intravenous analgesia(PCIA) and changes of serum S-100β protein, interleukin 6(IL-6), interleukin 10(IL-10), tumor necrosis factor α(TNF-α), incidence of POCD were compared between the two groups. Results VAS and Ramsay scores of the observation group were lower than those of the control group at 4 h, 12 h, 24 h and 48 h after surgery(P<0.05). At 1 h and 24 h after surgery, the number of self-controlled compressions and sufentanil dosage in the observation group were lower than those in the control group(P<0.05). 1 d, 3 d and 5 d after surgery, MMSE score and POCD incidence in the observation group were lower than those in the control group(P<0.05). On 1 d, 3 d and 5 d after surgery, IL-6, IL-10, TNF-α and S-100β in both groups showed a downward trend, and all indexes in the observation group were lower than those in the control group(P<0.05). Conclusions Flurbiprofen axetil assisted sufentanil in elderly patients with cervical cancer after surgery can reduce early postoperative cognitive disorder.

关 键 词：氟比洛芬酯 舒芬太尼 老年宫颈癌 认知功能 

分 类 号：R711[医药卫生—妇产科学]