扶正排毒祛湿汤治疗宫颈上皮内瘤变Ⅰ级伴持续高危型人乳头瘤病毒感染的临床研究  

Analysis of the therapeutic effect of Fuzhengpaiduqushi decoction in CIN Ⅰ with persistent high-risk human papilloma virus infection

作　　者：孙军华[1] 焦晓云[1] 李瑾[1] 王伟[1] SUN Junhua;JIAO Xiaoyun;LI Jin;WANG Wei(Department of Obstetrics and Gynecology,Hebei Civil Affairs General Hospital,Xingtai 054000,Hebei,China)

机构地区：[1]河北省民政总医院妇产科,河北邢台054000

出　　处：《中国性科学》2021年第11期128-131,共4页Chinese Journal of Human Sexuality

基　　金：邢台市科技计划项目(2014Zc122)。

摘　　要：目的探讨扶正排毒祛湿汤对低级别宫颈上皮内瘤变(CINⅠ级)伴持续高危型人乳头瘤病毒(HPV)感染的疗效分析。方法选取2018年1月至2020年1月河北省民政总医院诊治的86例CINⅠ级伴持续高危型HPV感染患者作为研究对象。采用随机数字表法分为研究组和常规组,各43例。常规组予以阴道用重组人干扰素α2b治疗,研究组在常规组治疗基础上予以扶正排毒祛湿汤治疗。观察并比较两组治疗前后症状体征评分和病毒载量变化、临床疗效、治疗前后T细胞免疫水平变化以及不良反应发生情况。结果两组治疗后症状体征评分、病毒载量、CD8^(+)占比均较治疗前下降,且研究组治疗后上述指标均低于常规组,两组治疗后CD3^(+)占比、CD4^(+)占比、CD4^(+)/CD8^(+)均较治疗前升高,且研究组治疗后上述指标均高于常规组,差异具有统计学意义(P<0.05);两组临床疗效分布比较,差异具有统计学意义(P<0.05);研究组总有效率高于常规组,差异具有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论对CINⅠ级伴持续高危型HPV感染患者应用扶正排毒祛湿汤治疗,可减轻其临床症状,改善体征,控制病毒载量,增强临床疗效和T细胞免疫功能,且安全可靠。Objective To explore the therapeutic effect of Fuzhengpaiduqushi decoction in low-level cervical intraepithelial neoplasia(CIN Ⅰ) with persistent high-risk human papilloma virus(HPV) infection. Methods 86 cases of CIN Ⅰ patients with persistent high-risk HPV infection treated in Hebei Civil Affairs General Hospital from January 2018 to January 2020 were selected as the study subjects. Random number table method was used to divide them into study group and routine group, 43 cases in each group. The routine group was treated with recombinant human interferon α2 b, and the study group was treated with Fuzhengpaiduqushi decoction on the basis of the routine treatment. The changes of symptom and sign score, viral load, clinical efficacy, T-cell immune level and adverse reactions before and after treatment were observed and compared between the two groups. Results After treatment, the scores of symptoms and signs, viral load, and the proportion of CD8;in both groups were lower than those before treatment, which in the study group were lower than the routine group. CD3^(+)and CD4^(+)and CD4^(+)/CD8^(+)in the both groups were higher than those before treatment, which in the study group were higher than the routine group after treatment, with statistical significant differences(P<0.05). There was a significant difference in the distribution of clinical effect between the two groups(P<0.05). The total effective rate in the study group was higher than that in the routine group, with a statistically significant difference(P<0.05). There was no significant difference in the incidences of adverse reactions between the two groups(P>0.05). Conclusions The application of Fuzhengpaiduqushi decoction in CIN Ⅰ patients with persistent high-risk HPV infection can reduce symptoms, improve physical signs, control viral load, enhance clinical efficacy and T cell immune function, which is safe and reliable.

关 键 词：中药 宫颈上皮内瘤变 人乳头瘤病毒 

分 类 号：R711[医药卫生—妇产科学]