阴虚体质早期先兆流产患者的中西医结合疗效观察  

Observation on curative effect of integrated traditional Chinese and Western medicine in early threatened abortion patients with Yin deficiency constitution

作　　者：单伟斌 盖其婷 邢莹莹 SHAN Weibin;GAI Qiting;XING Yingying(Department of Gynecology and Obstetrics,Benq Hospital,Nanjing Medical University,,Nanjing 210019,Jiangsu,China;Department of Obstetrics and Gynecology,Xuchang Maternal and Child Health Hospital,Xuchang 461000,Henan,China)

机构地区：[1]南京医科大学附属明基医院妇产科,南京210019 [2]许昌市妇幼保健院妇产科,河南许昌461000

出　　处：《中国性科学》2021年第11期138-141,共4页Chinese Journal of Human Sexuality

摘　　要：目的观察中西医结合治疗阴虚体质早期先兆流产患者的临床效果。方法选取2019年3月至2020年2月南京医科大学附属明基医院收治的120例阴虚体质的早期先兆流产患者作为研究对象。采用随机数字表法将其分为研究组和对照组,各60例。对照组采用常规治疗(黄体酮软胶囊治疗和日常调理),研究组在常规治疗的基础上采用滋肾益阴安胎之寿胎丸加女贞子、旱莲草、地黄治疗配合综合调理。两组均治疗3周,比较两组治疗前后的中医症状评分、血清β-人绒毛膜促性腺激素(β-HCG)、孕酮(P)、雌二醇(E_(2))、γ-干扰素(IFN-γ)、白细胞介素-4(IL-4)、IFN-γ/IL-4以及临床疗效和安全性。结果治疗后,两组主症评分、次症评分、总分均低于治疗前,且研究组主症评分、次症评分、总分均低于对照组,差异具有统计学意义(P<0.05);研究组总有效率高于对照组,差异具有统计学意义(P<0.05);两组血清β-HCG、P、E_(2)、IL-4水平在治疗后均升高,且研究组治疗后血清β-HCG、P、E_(2)、IL-4水平均高于对照组,差异具有统计学意义(P<0.05);两组血清IFN-γ、IFN-γ/IL-4水平在治疗后均下降,且研究组治疗后血清IFN-γ、IFN-γ/IL-4水平均低于对照组,差异具有统计学意义(P<0.05);两组不良反应均可耐受,且两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗的基础上,对阴虚体质先兆流产患者应用滋肾益阴安胎之寿胎丸加女贞子、旱莲草、地黄治疗配合综合调理,可显著减轻症状,增强疗效,提高血清β-HCG、P、E_(2)水平,调节Th1/Th2平衡,且安全性好。Objective To observe the clinical effect of integrated traditional Chinese and Western medicine on early threatened abortion patients with Yin deficiency constitution. Methods 120 cases of threatened abortion patients with Yin deficiency in Benq Hospital, Nanjing Medical University from March 2019 to February 2020 were selected and divided into control group and study group by a random digital table, with 60 cases in each group. The control group was given routine treatment(progestin soft capsule treatment and daily care), while the research group was treated with Zishenyiyinantaishoutai pills plus NvZhenZi, Eclipta, Rehmannia glutinosa combined with comprehensive care on the basis of routine method, both for 3 weeks. TCM symptom score, serum β-human chorionic gonadotropin(β-HCG), progesterone(P), estradiol(E_(2)), interferon-γ(IFN-γ), interleukin-4(IL-4), IFN-γ/IL-4 and clinical efficacy and safety were compared between the two groups before and after treatment. Results The main symptom score, secondary symptom score and total score of 2 groups after treatment were lower than before, and the main symptom score, secondary symptom score and total score of study group were lower than those of control group(P<0.05). The total effective rate of the study group was higher than that of the control group(P<0.05). The levels of serum β-HCG, P, E_(2)and IL-4 in 2 groups were increased after treatment, and those in study group were higher than those in control group after treatment(P<0.05). The levels of serum IFN-γ and IFN-γ/IL-4 in both groups decreased after treatment, and those in the study group were lower than those in the control group after treatment(P<0.05). Adverse reactions were tolerable in both groups, and there was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05). Conclusions On the basis of routine method, the Zishenyiyinantaishoutai pills plus NvZhenZi, Eclipta, Rehmannia glutinosa combined with comprehensive care in threatened abortion patients with Y

关 键 词：先兆流产 阴虚体质 临床疗效 Β-人绒毛膜促性腺激素 孕酮 雌二醇 

分 类 号：R275[医药卫生—中医皮科] R714[医药卫生—中医学]