机构地区:[1]国家老年疾病临床医学研究中心,解放军总医院第二医学中心心血管内科,北京100853 [2]国家老年疾病临床医学研究中心,解放军总医院第二医学中心老年医学研究所,北京100853 [3]江西省吉安县中医院心血管内科
出 处:《中华老年心脑血管病杂志》2021年第12期1240-1243,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基 金:军队保健专项科研课题(20BJZ43);解放军总医院第二医学中心应用基础研究项目(ZXD2007)。
摘 要:目的探讨血清尿酸/肌酐比值与老年女性代谢综合征(MS)及其组分的相关性。方法选择老年女性863例,根据诊断分为MS组449例,非MS组414例。又根据基线尿酸/肌酐比值四分位数分为4组:Q1组215例,Q2组216例,Q3组216例,Q4组216例。采用多因素logistic回归分析评估基线尿酸/肌酐比值水平与MS及其组分的相关性。结果 MS组年龄、糖尿病、高血压、收缩压、舒张压、腰围、体质量指数、空腹血糖、糖化血红蛋白、TG、TC、LDL-C、尿酸、尿酸/肌酐比值及MS组分个数明显高于非MS组,估算的肾小球滤过率和HDL-C水平明显低于非MS组(P<0.05,P<0.01)。Q4组年龄明显低于Q1组、Q2组和Q3组,高血压、腰围、体质量指数、TG、尿酸、MS患病率及MS组分个数明显高于Q1组、Q2组和Q3组(P<0.05)。多因素logistic回归分析显示,Q2组、Q3组和Q4组MS风险分别为Q1组的1.43倍、1.64倍和3.16倍(P<0.01)。尿酸/肌酐比值每升高1个单位,MS风险增加46%(95%CI:1.27~1.68,P<0.01)。尿酸/肌酐比值与腹型肥胖、高血压和高TG呈正相关(P<0.01)。ROC曲线分析显示,基线尿酸/肌酐比值对MS预测的曲线下面积为0.60(95%CI:0.56~0.64,P<0.01),截断值4.95。结论尿酸/肌酐比值与老年女性MS风险相关,与MS组分腹型肥胖、高血压、高TG也相关。尿酸/肌酐比值可能用作老年女性MS的预测指标之一。Objective To study the association of serum UA to creatinine(SUA/Cr) ratio with metabolic syndrome(MS) and its components in elderly women.Methods Eight hundred and sixty-three ≥60 years old women were divided into MS group(n=449) and MS-free group(n=414) according to the MS diagnostic criteria and into Q1 group(n=215),Q2 group(n=216),Q3 group(n=216) and Q4 group(n=216) according to the baseline SUA/Cr ratio.The association of baseline SUA/Cr ratio with MS and its components in elderly women was analyzed by multivariate logistic regression analysis.Results The age was significantly older, the waist circumference was significantly longer, the incidence of DM and hypertension, SBP,DBP,BMI,serum levels of FBG,HbA1 c, TC, TG, LDL-C,UA,and SUA/Cr ratio were significantly higher, the number of MS components was significantly greater while the eGFR and serum HDL-C level were significantly lower in MS group than in MS-free group(P<0.05,P<0.01).The age was significantly younger while the waist circumference was significantly longer, the incidence of MS and hypertension, BMI,serum TG and UA levels were significantly higher, the number of MS components was significantly greater in Q4 group than in Q1,Q2 and Q3 groups(P<0.05).Multivariate logistic regression analysis showed that the risk of MS was 1.43-,1.64-and 3.16-fold higher respectively in Q2,Q3 and Q4 groups than in Q1 group after adjustment for age, TC and LDL-C(P<0.01).The risk of MS increased by 46% in elderly women when the SUA/Cr ratio increased by per 1 unit(95%CI:1.27-1.68,P<0.01).The SUA/Cr ratio was positively associated with central obesity, hypertension and high serum TG level in elderly women(P<0.01).ROC curve analysis showed that the AUC of baseline SUA/Cr ratio for predicting MS was 0.60(95%CI:0.56-0.64,P<0.01) with an optimal cut-off value of 4.95.Conclusion The SUA/Cr ratio is positively associated with the risk of MS and its components(such as central obesity, hypertension and high serum TG level) in elderly women.The SUA/Cr ratio can thus be used as
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