老年男性冠心病患者尿酸与肾功能的相关性分析  

Relationship between serum UA and renal function in elderly male CHD patients

作　　者：朱兵[1] 李昂[1] 刘宏伟[1] 王亮[1] 曹瑞华[1] Zhu Bing;Li Ang;Liu Hongwei;Wang Liang;Cao Ruihua(Department of Cardiology,Chinese PLA General Hospital No.2 Medical Center,National Clinical Research Center for Geriatric Diseases,Beijing 100853,China)

机构地区：[1]解放军总医院第二医学中心心血管内科,国家老年疾病临床医学研究中心,北京100853

出　　处：《中华老年心脑血管病杂志》2021年第12期1252-1255,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家老年疾病临床医学研究中心开放课题(NCRCG-PLAGH-2019018)。

摘　　要：目的探讨老年男性冠心病患者尿酸与肾功能的相关性。方法选择2018年3~8月解放军总医院第二医学中心门诊体检的老年男性冠心病患者755例,根据尿酸水平分为尿酸正常组621例(尿酸<420μmol/L),高尿酸血症组134例(尿酸≥420μmol/L)。收集入选者临床基线资料,检测N末端B型钠尿肽前体(NT-proBNP),并计算估算的肾小球滤过率(eGFR),分析尿酸与肾功能的相关性。结果与尿酸正常组比较,高尿酸血症组尿酸、NT-proBNP水平和降尿酸药物比例明显升高,舒张压、HDL-C、eGFR水平明显降低(P<0.05,P<0.01)。Pearson相关性分析显示,eGFR与HDL-C呈正相关(r=0.092,P=0.011),与年龄、尿酸、NT-proBNP、糖化血红蛋白呈负相关(r=-0.263,P=0.001;r=-0.347,P=0.001;r=-0.230,P=0.001;r=-0.233,P=0.001)。多元线性回归分析显示,在校正多种传统心血管危险因素后,尿酸与eGFR呈负相关(P<0.01)。冠心病合并糖尿病患者尿酸与eGFR负相关更显著(P<0.01)。结论在老年男性冠心病患者中,血清尿酸水平与肾功能指标eGFR相关,且在冠心病合并糖尿病患者中相关性更显著。Objective To study the relationship between serum UA and renal function in elderly male CHD patients.Methods Seven hundred and fifty-five elderly male CHD patients who underwent physical examination in our center from March 2018 to August 2018 were divided into normal serum UA(<420 μmol/L) group(n=621) and hyperuricemia(serum UA ≥420 μmol/L) group(n=134).Their baseline clinical data were recorded, their serum NT-proBNP level and eGFR were measured.The relationship between serum UA and renal function in elderly male CHD patients was analyzed.Results The serum NT-proBNP level and ratio of used UA lowering drugs were significantly higher while the DBP,serum HDL-C level and eGFR were significantly lower in hyperuricemia group than in normal serum UA group(P<0.05,P<0.01).Pearson correlation analysis showed that eGFR was positively related with serum HDL-C level(r=0.092,P=0.011) and negatively related with age, serum UA,NT-proBNP and HbA1 c levels in elderly male CHD patients(r=-0.263,P=0.001;r=-0.347,P=0.001;r=-0.230,P=0.001;r=-0.233,P=0.001).Multivariate linear logistic regression analysis displayed that UA was negatively related with eGFR in male CHD patients and more significantly in male CHD patients with DM after adjustment of traditional risk factors for cardiovascular disease(P<0.01).Conclusion Serum UA is related with eGFR in elderly male CHD patients and more significantly in elderly male CHD patients with DM.

关 键 词：冠心病 尿酸 高尿酸血症 肾小球滤过率 糖尿病 

分 类 号：R541.4[医药卫生—心血管疾病]