针刺治疗慢性疲劳综合征的实验指标选取及机制研究现状  

Current state about researches on selection of experimental indexs mechanisms of acupuncture underlying improvement of chronic fatigue syndrome

作　　者：李艳慧 马巧琳[1,2] 胡斌[1,2] 王钟磊 LI Yan-hui;MA Qiao-lin;HU Bin;WANG Zhong-lei(Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450003)

机构地区：[1]河南中医药大学,郑州450046 [2]河南中医药大学第三附属医院,郑州450003

出　　处：《针刺研究》2021年第11期980-984,共5页Acupuncture Research

基　　金：河南省中医药科学研究专项项目(No.2019ZY1025);国家中医药管理局全国中医药创新骨干人才培训项目(No.国中医药人教函〔2019〕128号)。

摘　　要：针刺治疗慢性疲劳综合征(CFS)疗效肯定,具有自身独特优势。本文通过检索近10年针刺治疗CFS的基础研究文献,发现其主要作用机制及指标涉及以下几个方面:1)调节免疫系统,包括外周免疫器官、免疫细胞和免疫细胞因子、促炎细胞因子和抗炎细胞因子,降低多重支原体感染阳性率的上升;2)调节神经内分泌系统,包括下丘脑-垂体-肾上腺轴和应激激素、单胺类神经递质和阿片肽;3)通过降低丙二醛、上调超氧化物歧化酶和谷胱甘肽过氧化物酶活性来提高抗氧化应激能力;4)调控基因和蛋白质组学技术揭示的多种细胞分子信号通路。总之,针刺能够从多个系统和途径改善CFS,本研究可能为相关机制研究提供新的思路。Acupuncture therapy is effective in the treatment of chronic fatigue syndrome(CFS)and has its own unique advantages.In the present paper,we reviewed the progress of experimental researches on the underlying mechanisms of acupuncture treatment of CFS in recent 10years from:1)regulating the immune system including the peripheral immune organ,immune cells and immune cytokines,proinflammatory and anti-inflammatory cytokines,and lowering the increase of positive rate of multiple mycoplasma infection;2)regulating the neuroendocrine system including the hypothalamus-pituitary-adrenal axis and stress hormones,monoamine neurotransmitters,and opioid peptides;3)raising the anti-oxidative stress ability by reducing malondiadehyde,and upregulating activities of antioxidant enzymes superoxide dismutase and glutathione peroxidase;and 4)regulating multiple cellular molecule signaling pathways revealed by genomic and proteomic technologies.In conclusion,acupuncture can relieve CFS through multiple ways and systems,which may provide some ideas for further studies on the biological mechanisms.

关 键 词：慢性疲劳综合症 针刺疗法 实验研究 综述 

分 类 号：R246.1[医药卫生—针灸推拿学]