银杏叶联合酒石酸美托洛尔治疗冠心病的应用效果  

Application Effect of Ginkgo Biloba Dripping Pills Combined with Metoprolol Tartrate in the Treatment of Patients with Coronary Heart Disease

作　　者：范一风 杨光耀 FAN Yi-feng;YANG Guang-tao(Department of Cardiology,Pingding Shan Second People's Hospital,Pingdingshan 467000 China)

机构地区：[1]河南平顶山市第二人民医院心血管内科,河南平顶山467000

出　　处：《内蒙古医学杂志》2021年第11期1303-1306,共4页Inner Mongolia Medical Journal

摘　　要：目的探讨银杏叶滴丸联合酒石酸美托洛尔在冠心病(CHD)临床治疗中的应用价值。方法选取2018年12月至2020年4月我院134例CHD患者,按照随机数表法分为治疗组与对照组,每组67例。饮食、生活指导及常规治疗基础上,对照组给予酒石酸美托洛尔,治疗组给予酒石酸美托洛尔+银杏叶滴丸,均治疗8周。对比两组临床疗效、治疗前后心功能[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)]、外周血toll样受体4(TLR4)/核因子(NF-κB)mRNA表达、生活质量(SAQ评分)及治疗期间不良反应发生率。结果(1)临床疗效:治疗组治疗总有效率92.54%(62/67)高于对照组80.60%(54/67)(P<0.05);(2)心功能:治疗后治疗组LVESD、LVEDD小于对照组,LVEF高于对照组(P<0.05);(3)TLR4/NF-κB mRNA表达:治疗后治疗组外周血TLR4、NF-κB mRNA表达低于对照组(P<0.05);(4)生活质量:治疗后治疗组SAQ各维度评分高于对照组(P<0.05);(5)安全性:治疗期间两组眩晕、头痛、疲倦、失眠、胃部不适等不良反应发生率比较无显著差异(P>0.05)。结论银杏叶滴丸联合酒石酸美托洛尔治疗CHD效果显著,可有效改善患者心功能,可能与抑制外周血TLR4/NF-κB信号通路过度激活有关,且有利于改善患者生活质量,安全性亦有保障。Objective To investigate the application value of Ginkgo biloba drop pills combined with meto-prolol tartrate in the clinical treatment of coronary heart disease(CHD).Methods A total of 134 patients with CHD from our hospital from December 2018 to April 2020 were enrolled in the treatment group and the control group according to the random number table method,with 67 cases in each group.On the basis of diet,life guid-ance and routine treatment,the control group was given metoprolol tartrate,and the treatment group was given metoprolol tartrate+ginkgo biloba drop pills for 8 weeks.Compare the clinical efficacy of the two groups,cardiac function before and after treatment[left ventricular end-systolic diameter(LVESD),left ventricular end-dias-tolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],peripheral blood toll-like receptor(TLR4)/Nuclear factor(NF-κB)mRNA expression,quality of life(SAQ score)and incidence of adverse reactions during treatment.Results(1)Clinical efficacy:The total effective rate of treatment in the treatment group was 92.54%(62/67)higher than that in the control group(80.60%(54/67)(P<0.05);(2)cardiac function:treatment group LVESD,LVEDD was lower than the control group,LVEF was higher than the control group(P<0.05).(3)TLR4/NF-κB mRNA expression:The expression of TLR4 and NF-κB mRNA in the peripheral blood of the treatment group was lower than that of the control group(P<0.05).(4)Quality of life:The scores of SAQ in the treatment group were higher than those in the control group(P<0.05);(5)Safety:2 groups of dizziness,head-ache,fatigue,insomnia,stomach discomfort and other adverse reactions occurred during treatment There was no significant difference in the rate(P>0.05).Conclusion Ginkgo biloba drop pills combined with metoprolol tar-trate in the treatment of CHD can significantly improve the heart function of patients,which may be related to the inhibition of excessive activation of TLR4/NF-κB signaling pathway in peripheral blood,and is conducive to im-proving patients'quality

关 键 词：冠心病 酒石酸美托洛尔 银杏叶滴丸 心功能 

分 类 号：R541[医药卫生—心血管疾病]