膀胱组织工程:膀胱替代治疗的新希望  

Bladder tissue engineering:anew hope for bladder replacement therapy

作　　者：凌争云 赵健[1] 符伟军[1] 张旭[1] Ling Zhengyun;Zhao Jian;Fu Weijun;Zhang Xu(Department of Urology,the First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心泌尿外科,北京100853

出　　处：《中华实验外科杂志》2021年第12期2534-2537,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81873600)。

摘　　要：各种原因导致膀胱切除后的替代治疗是临床亟待解决的难题,目前治疗金标准是采用传统的胃肠道替代膀胱重建术,然而并发症多而影响患者生活质量,膀胱组织工程的发展为膀胱重建提供了新的解决方案。近年来的研究在往新材料支架、多种材料结合支架、生长因子缓释系统、3D打印技术等方向发展。本文将介绍膀胱组织工程的最新进展,遇到的困难以及分析其原因,探讨未来发展的可能方向。Replacement therapy after cystectomy is a difficult problem to be solved,currently the gold standard of treatment for bladder reconsturction is to use the traditional intestinal tract replace bladder.However,many complications affect the quality of life of patients,The development of bladder tissue engineering provides a new solution for bladder reconstruction.In recent years,the research is developing in the direction of new material scaffolds,multi-materialscaffolds,growth factor release system,3D printing technology and so on.This article will introduce the latest progress of bladder tissue engineering,the difficulties encountered and analyze the reasons,and explore the possible direction of future development.

关 键 词：膀胱重建 组织工程 3D打印 种子细胞 生长因子 

分 类 号：R699[医药卫生—泌尿科学] R318.08[医药卫生—外科学]