元代以前、明清时期及近现代骨痹内治方药的用药规律及变化研究  

Medication rule of oral drugs on bone rheumatism in different historical stages and its changes

作　　者：王明亮 梁明 高琼 王功国[1] 韩光明[2] WANG Mingliang;LIANG Ming;GAO Qiong;WANG Gongguo;HAN Guangming(Department of Orthopedics,Rizhao Hospital of Traditional Chinese Medicine,Rizhao,Shandong 276800;不详)

机构地区：[1]山东省日照市中医医院骨科,山东日照276800 [2]山东省日照市中医医院药剂科,山东日照276800

出　　处：《河北中医》2021年第8期1379-1382,共4页Hebei Journal of Traditional Chinese Medicine

基　　金：山东省卫生健康委员会2021年中医药高层次人才培育项目;山东省卫生健康委员会2019-2020年度中医药科技发展计划项目(编号:2019-0802);2020年度山东省中医药科技项目(编号:2020Z49)。

摘　　要：目的对元代以前、明清时期及近现代骨痹相关文献进行系统整理研究,统计分析不同时期骨痹内治方药的用药规律。方法查录秦汉至近现代医学著作,建立骨痹治疗的方剂数据库,对不同时期所用方药进行统计分析,比较不同时期治疗骨痹所用方药在功效、四气、五味、归经方面用药特点的变化规律。结果元代以前应用频数最高的3类药物依次为补虚药、温里药、活血化瘀药,明清时期应用频数最高的3类药物依次为补虚药、解表药、活血化瘀药,近现代应用频数最高的3类药物依次为补虚药、活血化瘀药、祛风湿药。元代以前补虚药使用频率与明清时期比较差异有统计学意义(P<0.05),元代以前、明清时期活血化瘀药、祛风湿药使用频率与近现代比较差异有统计学意义(P<0.05),3个时期补虚药、活血化瘀药、祛风湿药使用频率组间比较差异有统计学意义(P<0.05)。元代以前应用频率最高的3类药物的药性依次为温、平、热,明清时期及近现代应用频率最高的3类药物的药性依次为温、平、寒。3个时期温性、热性、寒性药物使用频率比较差异均有统计学意义(P<0.05)。元代以前应用频率最高的3类药物的药味依次为辛、甘、苦,明清时期及近现代应用频率最高的3类药物的药味依次为甘、辛、苦。3个时期辛、苦、咸、酸味药物使用频率组间比较差异有统计学意义(P<0.05)。元代以前应用频率最高的3类药物归经依次为肝经、心经、肾经,明清时期及近现代应用频率最高的3类药物归经依次为肝经、心经、脾经。3个时期肝经、肾经、脾经、肺经、膀胱经、胃经药物使用频率组间比较差异有统计学意义(P<0.05)。结论通过分析不同时期骨痹内治方药的用药规律,可以看出历代医家治疗骨痹均多用固肾补虚、活血化瘀,辛开苦燥、甘温并补之药,平调脏腑,标本兼顾。明清时期及�Objective To study medication rule of oral drugs on bone rheumatism in different historical stages(before Yuan Dynasty,Ming and Qing dynasties and modern times)by systematic research of related literature.Method:We consulted medical works since Qin and Han Dynasties,performed statistical analysis of oral drugs on bone rheumatism in different stages by establishing a database,and compared medication rule in terms of efficacy,four qi,five wei,meridian.Results The 3 commonly in drug application were Buxu drug,Wenli drug,Huoxue Huayu drug before Yuan Dynasty,Buxu drug,Jiebiao durg,Huoxue Huayu drug on Ming and Qing Dynasties,and Buxu drug,Huoxue Huayu drug,Qufengshi drug on Modern times(P<0.05).the application frequency of buxu drug were significant difference before the Yuan Dynasty vs Ming and Qing Dynasties(P<0.05),and with significantly different in application frequency of Huoxue Huayu drug and Qufengshi drug on Ming and Qing Dynasties vs modern times(P<0.05),the application frequency of the above three were similar during the three stages(P<0.05).The application frequency in drug properties were 3 commonly as warm,calm and hot before the Yuan Dynasty;and warm,calm,and cold on Ming and Qing Dynasties and modern times;difference was significant of them in the three periods(P<0.05).The application frequency of drug taste were bitter,salty,and sour drugs,there was significant difference in the use of them in the three periods(P<0.05).The application frequency of drugs meridian were mainly the liver meridian,heart meridian,kidney meridian before Ming Dynasty;and liver meridian,heart meridian,spleen meridian on Ming and Qing Dynasties,liver meridian,kidney meridian,spleen meridian,lung meridian,as well as stomach meridian on modern times,and with a statistically significant difference in the three stages(P<0.05).Conclusion The medication rule of oral drugs on bone rheumatism in different stages indicates that the application frequency of Gushen Buxu,Huaxue Huayu,Xinkai Kuzao,Ganwen Bingbu were more by the ancient phy

关 键 词：痹证 中医历代典籍 中药性味 归经 

分 类 号：R255.82[医药卫生—中医内科学] R28[医药卫生—中医学]