视黄酸对细胞凋亡的调控作用及机制  

Regulation and mechanism of all-trans-retinoic acid to apoptosis

作　　者：刘丽 赵智[2] 付琳 张丽[3,4] 董贤文 王高富 LIU Li;ZHAO Zhi;FU Lin;ZHANG Li;DONG Xianwen;WANG Gaofu(Chongqing Chemical Industry Vocational College,Chongqing 401228,China;Department of Economic Management,Party School of the Chongqing Municipal Committee of CPC,Chongqing 400041,China;Chongqing Academy of Animal Sciences,Chongqing 402460,China;Chongqing Engineering Research Center for Goat,Chongqing 402460,China)

机构地区：[1]重庆化工职业学院,重庆401228 [2]中共重庆市委党校经济管理教研部,重庆400041 [3]重庆市畜牧科学院,重庆402460 [4]重庆市山羊工程技术研究中心,重庆402460

出　　处：《中国饲料》2021年第23期8-13,共6页China Feed

基　　金：国家自然科学基金项目(32002206);重庆市自然科学基金重点研发项目(cstc2020jcyj-zdxmX0005);重庆市2019年科研机构绩效激励引导专项(19233)。

摘　　要：视黄酸(RA)是维生素A在动物机体内的代谢终产物和功能性物质,已经证明其对动物健康和生产性能具有重大影响,但是具体机制尚不明确。细胞凋亡是动物细胞维持正常生长和生产的重要方式。本文从RA在体内合成及转运、细胞凋亡信号通路和RA对细胞凋亡调控机制3个方面,对RA调控细胞凋亡的双向作用和机制进行综述,以期为RA在动物饲养和健康维持方面的应用与研究提供理论支撑。All-trans-retinoic acid(RA)has been demonstrated with important effect on animal health and production performance as the terminal metabolic and functional molecular of vitamin A.But the regulated mechanism is still unclear.Apoptosis is one of the most important way to maintain the growth and production of animal.Therefore,this paper reviewed three parts related to the way of RA synthesis and transportation,the signaling pathway of apoptosis and the apoptosis regulation mechanism of RA,aimed to supply more theoretical support for application and research of RA on animal feed and health maintenance.

关 键 词：视黄酸 细胞凋亡 调控 机制 

分 类 号：S811.2[农业科学—畜牧学]