Rhizopus microsporus lung infection in an immunocompetent patient successfully treated with amphotericin B:A case report  

作　　者：Long Chen Yuan Su Xian-Zhi Xiong 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430022,Hubei Province,China

出　　处：《World Journal of Clinical Cases》2021年第35期11108-11114,共7页世界临床病例杂志

摘　　要：BACKGROUND Rhizopus microsporus(R.microsporus)lung infection is an invasive fungal disease with high mortality that is increasingly common in immunocompromised patients.However,it is very rare in immunocompetent patients.Here,we present the case of a 19-year-old girl who developed R.microsporus lung infection without any known immunodeficiency.CASE SUMMARY The patient presented to our hospital because of hemoptysis and irritative cough without expectoration.She was first treated for community-acquired pneumonia until the detection of R.microsporus in bronchoalveolar lavage fluid by metagenomics next-generation sequencing(mNGS).After a combination therapy of intravenous inhalation and local airway perfusion of amphotericin B,she eventually recovered,with significant absorption of lung infections.CONCLUSION Early diagnosis and treatment are very important for pulmonary mucormycosis.Compared to fungal culture,mNGS is a relatively precise and convenient method to obtain pathogenic results.A combination therapy of intravenous inhalation and local airway perfusion of amphotericin B may be a promising strategy for the treatment of pulmonary mucormycosis in the future.

关 键 词：Rhizopus microsporus Immunocompetent patient Pulmonary mucormycosis Amphotericin B Case report 

分 类 号：R563.1[医药卫生—呼吸系统]