抑郁症患者性激素异常及治疗的研究进展  

Development on hormone abnormalities and treatment in patients with major depression

作　　者：陈美惠[1] 贾佳[1] 曹燕丽(综述)[1] 龚光明(审校)[2] CHEN Mei-hui;JIA Jia;CAO Yan-li;GONG Guang-ming(Department of Pharmacy,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China;Department of Medical Engineering,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China)

机构地区：[1]东部战区总医院(原南京军区南京总医院)药剂科,南京210002 [2]东部战区总医院(原南京军区南京总医院)医学工程科,南京210002

出　　处：《东南国防医药》2021年第6期633-636,共4页Military Medical Journal of Southeast China

基　　金：国家自然科学基金(31671026)。

摘　　要：卵巢激素的波动与抑郁风险增加有关。用于预防怀孕或使月经周期正常的口服避孕药,有可能改变情绪,但仅用孕激素减轻抑郁症状相关的证据不足。卵巢激素对情绪的作用,受多重因素的影响。研究表明,通过口服避孕药抑制排卵和GnRH激动剂的联用对经前期综合征有一定效果。另外,更年期的早期实施雌激素替代疗法(ERT)或激素替代疗法(HRT)是最有效的进行抑郁干预的方法。患抑郁症的中、老年男性总睾酮和游离睾酮水平均低于正常男性,睾酮可能是治疗轻度抑郁症的有效方法,脱氢表雄酮对HIV阳性患者的轻度抑郁有疗效。文章就抑郁症患者激素治疗最新进展进行综述。Fluctuations in ovarian hormones are associated with an increased risk of depressive states.Oral contraceptives,used to prevent pregnancy or normalize the menstrual cycle,have been thought to potentially alter mood.However,there has been scant evidence linking progesterone-only contraceptives to depressive symptoms.Estrogen replacement therapy(ERT)or hormone replacement therapy(HRT)is the most effective way to intervene with depression in the early stages of menopausal transition.Iterogesterone has significant anti-anxiety and antidepressant properties,as well as the ability to inhibit HPA axis activity.In middle and later life,both total and free testosterone levels were lower in men with major depressive disorder than in men without depression.Testosterone may be an effective treatment for depressive symptoms in NMDD,and DHEA has been shown to be effective in NMDD in HIV-positive patients.

关 键 词：抑郁症 性激素 异常 临床 治疗 

分 类 号：R458.7[医药卫生—治疗学]