阿尔茨海默病患者尿路感染的病原学特点及危险因素分析  

Etiological characteristics and risk factors for urinary tract infection in patients with Alzheimer's disease

作　　者：罗贤海 肖菊艳 陈寿林 邱聪龙 田海华 LUO Xianhai;XIAO Juyan;CHEN Shoulin;QIU Conglong;TIAN Haihua(Department of Laboratory Medicine,Ningbo Kangning Hospital,Ningbo 305201,China;Department of Geriatrics,Ningbo Kangning Hospital,Ningbo 305201,China)

机构地区：[1]宁波市康宁医院检验科,浙江宁波305201 [2]宁波市康宁医院老年科,浙江宁波305201

出　　处：《中国现代医生》2021年第29期134-137,共4页China Modern Doctor

基　　金：浙江省宁波市医学重点学科精神病学(2016-G02)。

摘　　要：目的分析阿尔茨海默病合并尿路感染的病原学特点及危险因素,为尿路感染预防、控制和治疗工作提供参考依据。方法分析宁波市康宁医院2015年6月至2020年6月住院的670例阿尔茨海默病患者发生尿路感染的感染率,观察发生尿路感染患者的尿路临床特征,分析尿路感染患者病原菌分布特点,采用单因素及多因素回归分析发生尿路感染的危险因素。结果156例患者发生尿路感染,感染率为23.28%;尿频、尿急、尿痛等尿路刺激症状为主要临床表现;共分离出132株病原菌,以革兰阴性菌为主,共89株占67.42%;患者年龄、住院天数、联合应用抗菌药物、生活自理能力、合并基础疾病、留置导尿管是发生阿尔茨海默病合并尿路感染的独立危险因素(P<0.05)。结论阿尔茨海默病患者尿路感染病原菌以革兰阴性菌为主,与患者高龄、病程长、合并严重基础疾病、生活自理能力、留置导尿管等因素密切相关,临床应对相关危险因素采取针对性干预措施,提高阿尔茨海默病尿路感染的防治效率。Objective To analyze the etiological characteristics and risk factors for Alzheimer′s disease complicated with urinary tract infection,and provide reference for the prevention,control and treatment of urinary tract infection.Methods The infection rate of urinary tract infection in 670 patients with Alzheimer′s disease hospitalized in the Ningbo Kangning Hospital from June 2015 to June 2020 was observed.The clinical characteristics of urinary tract infection in patients with urinary tract infection were observed.The pathogen distribution characteristics were analyzed.Single-and multi-factor regression analyses were conducted to investigate the risk factors for urinary tract infection.Results There were 156 patients with urinary tract infection,with an infection rate of 23.28%.Urinary tract irritation symptoms,such as frequent urination,urgency,and dysuria,were the main clinical manifestations.A total of 132 pathogens were isolated,most of which were gram-negative bacteria,with 89 strains in total,accounted for 67.42%.Patients′age,length of hospitalization,combined use of antibiotics,self-care ability,complication of underlying diseases,and indwelling urinary catheter were independent risk factors for Alzheimer′s disease combined with urinary tract infection(P<0.05).Conclusion Gram-negative bacteria are the main pathogen in patients with Alzheimer′s disease complicated with urinary tract infection.The incidence of urinary tract infection is closely related to patients′age,long course of disease,complication of serious underlying diseases,self-care ability,indwelling catheterization and other factors.Targeted interventions should be implemented for corresponding risk factors in clinical practice,to improve the efficiency of prevention and treatment of urinary tract infection in patients with Alzheimer′s disease.

关 键 词：阿尔茨海默病 尿路感染 病原菌分布 危险因素 

分 类 号：R691.3[医药卫生—泌尿科学]