Regulating monocyte infiltration and differentiation:Providing new therapies for colorectal cancer patients with COVID-19  

作　　者：Ling Bai Wang Yang Lei Qian Jiu-Wei Cui 

机构地区：[1]Cancer Center,The First Hospital of Jilin University,Changchun 130021,Jilin Province,China

出　　处：《World Journal of Clinical Cases》2021年第34期10392-10399,共8页世界临床病例杂志

基　　金：the National Key Research and Development Program of New Coronary Pneumonia and Other Infectious Diseases Prevention Basic Research Orientation Project of China,No.2020YFA0707704(to Qian L);the Ministry of Science and Technology of the People’s Republic of China,No.2016YFC1303800(to Cui JW);the Interdisciplinary Research Funding Program of Jilin University,No.101832020DJX083(to Bai L);and the Outstanding Talent Cultivation Program for Doctoral Students in Norman Bethune Health Science Center of Jilin University(to Bai L).

摘　　要：The outbreak of coronavirus disease 2019(COVID-19)is a significant challenge for clinicians,especially for immunocompromised cancer patients.By analyzing the impact of COVID-19 on the immune microenvironment of colorectal cancer(CRC)patients at the tissue level and single-cell level,we found that CRC patients are more easily infected by severe acute respiratory syndrome coronavirus-2(SARSCoV-2),but promotion of infiltration and differentiation of monocytes makes them more likely to develop severe COVID-19.Because of the continuing activation of nuclear factor(NF)-κB and C-C chemokine receptor type 5(CCR5)signaling pathways in monocytes,imbalance of macrophage polarization can aggravate the cytokine release syndrome.Therefore,regulating the infiltration and differentiation of monocytes is helpful for the treatment of COVID-19 in CRC patients.

关 键 词：COVID-19 SARS-CoV-2 MONOCYTE MACROPHAGE Colorectal cancer 

分 类 号：R735.34[医药卫生—肿瘤]