Intracuff alkalinized lidocaine to prevent postoperative airway complications:A meta-analysis  

作　　者：Zhen-Xing Chen Zhou Shi Bin Wang Ye Zhang 

机构地区：[1]Department of Anesthesiology and Perioperative Medicine,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui Province,China [2]Department of Anesthesiology,The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2021年第34期10626-10637,共12页世界临床病例杂志

摘　　要：BACKGROUND Post-extubation cough is a common phenomenon in surgical patients undergoing general anesthesia,which can lead to potentially dangerous complications.In this meta-analysis,we evaluated the efficacy and safety of intracuff alkalinized lidocaine in patients with tracheal intubation to prevent cough and other airway complications during the perioperative period.AIM To perform a systematic review and meta-analysis of intracuff alkalinized lidocaine for the prevention of postoperative airway complications.METHODS PubMed,Embase,Cochrane,and Web of Science were searched for randomized controlled trials(RCTs)that compared intracuff alkalinized lidocaine to placebo.We used risk-of-bias assessment to assess the RCTs,and the quality of evidence was assessed using the grading of recommendations,assessment,development,and evaluations.RESULTS Twelve randomized trials(1175 patients)were analyzed.Meta-analysis showed that intracuff alkalinized lidocaine was associated with less cough compared to that produced by placebo[risk ratio(RR):0.38;95%confidence interval(CI):0.23-0.63].Similarly,intracuff alkalinized lidocaine was more effective than the control in reducing postoperative sore throat at 24 h(RR:0.19;95%CI:0.09-0.41)and postoperative hoarseness(RR:0.38;95%CI:0.21-0.69).CONCLUSION Intracuff alkalinized lidocaine is an effective adjuvant that can decrease airway complications,such as coughing,hoarseness,and sore throat.

关 键 词：COUGH HOARSENESS LIDOCAINE Sore throat Airway complication Intracuff META-ANALYSIS 

分 类 号：R614[医药卫生—麻醉学]