CRP、sCD14-ST、NAP联合检测对小儿呼吸道感染性疾病的诊断价值  

Diagnostic Value of Combined Detection of CRP,sCD14-ST and NAP in Children with Respiratory Tract Infectious Diseases

作　　者：刘平定 杨芳谊 LIU Ping-ding;YANG Fang-yi(Department of Pediatrics,Weinan Maternal and Child Health Hospital,Weinan Shaanxi,714000)

机构地区：[1]陕西省渭南市妇幼保健院儿科,陕西渭南714000 [2]杨凌示范区医院儿科,陕西杨凌712100

出　　处：《医学临床研究》2021年第11期1601-1603,1609,共4页Journal of Clinical Research

基　　金：陕西省卫生健康科研基金项目(2018C007)。

摘　　要：【目的】探讨C-反应蛋白(CRP)、可溶性白细胞分化抗原14亚型(SCD14-ST)、嗜中性粒细胞碱性磷酸酶(NAP)联合检测对小儿呼吸道感染性疾病的诊断价值。【方法】陕西省渭南市妇幼保健院儿科收治的50例呼吸道感染患儿为观察组,同期在本院健康体检小儿50例为对照组。比较两组血清CRP、sCD14-ST水平及NAP积分,比较病原菌不同的呼吸道感染患儿血清CRP、sCD14-ST水平及NAP积分;分析50例患儿CRP、sCD14-ST、NAP积分之间的相关性,比较CRP、sCD14-ST、NAP积分对呼吸道感染的诊断效能。【结果】观察组血清CRP、sCD14-ST 水平及NAP积分显著高于对照组(P<0.05);细菌呼吸道感染患儿血清CRP、sCD14-ST水平及NAP积分显著高于病毒和支原体呼吸道感染患儿,且差异有显著性(P<0.05);病毒呼吸道感染患儿血清CRP、sCD14-ST 水平及NAP积分显著高于支原体感染患儿(P<0.05)。50例患儿CRP水平与sCD14-ST,NAP积分均呈正相关(P<0.05),sCD14-ST与NAP积分呈正相关(P<0.05)。CRP、sCD14-ST、NAP均是呼吸道感染的独立危险因素(P<0.05);CRP、sCD14-ST、NAP联合检测对呼吸道感染的诊断效能明显优于各项单独检测(P<0.05)。【结论】呼吸道感染患儿血清CRP、sCD14-ST水平及NAP积分明显升高,三者联合检测可提高对小儿感染性呼吸道疾病的诊断价值。【Objective】To investigate the diagnostic value of combined detection of C-reactive protein(CRP).soluble cluster of differentiation 14 subtype(sCD14-ST)and neutrophil alkaline phosphatase(NAP)in children with respiratory tract infections.【Methods】A total of 50 children with respiratory tract infections(as observation group)and 50 healthy children with health examination(as control group)in our hospital were selected for the study.Serum CRP,sCD14-ST levels and NAP scores were compared between the two groups,and the scores of CRP,sCD14-ST and NAP were also analyzed in sick children infected by different pathogens.The correlation among CRP,sCD14-ST and NAP was analyzed,and the diagnostic efficacy of CPR,sCD14-ST and NAP for respiratory infection was compared as well.【Results】The ser-um CRP,sCD14-ST levels and NAP scores in the observation group were significantly higher than those in the control group(P<0.05).Serum CRP,sCD14-ST levels and NAP scores were significantly different in children with respiratory tract infection caused by different pathogens(P<0.05).The levels of serum CRP,sCD14-ST and NAP scores of chil dren with bacterial respiratory infections were significantly higher than those of children with viral and mycoplasma respiratory tract infections,and the difference was significant(P<10.05).And serum CRP,sCD14-ST and NAP levels of children with viral respiratory tract infections were significantly higher than those of children with mycoplasma infection(P<0.05).The results showed that CRP was positively correlated with sCD14-ST and NAP(P<0.05),moreover,sCD14-ST was positively correlated with NAP(P<0.05).CRP,sCD14-ST and NAP were independent risk factors for respiratory infection(P<0.05);The diagnostic efficacy of combined detection of the three for respiratory tract infection was significantly better than that of individual detection(P<0.05).【Conclusion】Serum CRP,sCD14-ST levels and NAP scores are significantly elevated in children with respiratory tract infections.The combined detection of

关 键 词：呼吸道感染/药物疗法 呼吸道感染/诊断 C反应蛋白质血液 

分 类 号：R56[医药卫生—呼吸系统]