M-CSF、β-Catenin因子在重度子痫前期患者血清中的表达及其临床意义  

Expression and Clinical Significance of M-CSF and β-Catenin in the Serum of Patients with Severe Preeclampsia

作　　者：刘艳云[1] 鄢晓燕 李赟 LIU Yan-yun;YAN Xiao-yan;LI Yun(Department of obstetrics,Huangshi Maternity&Childrens Health Hospital,Edong Healthcare Group/Women's&Children's Hospital Afflicated to Hubei Polytechnic University Huangshi Hubei 435003,China)

机构地区：[1]鄂东医疗集团黄石市妇幼保健院/湖北理工学院附属妇幼保健院产科,湖北黄石435003

出　　处：《医学临床研究》2021年第11期1618-1620,1624,共4页Journal of Clinical Research

基　　金：湖北省卫生健康委员会2019年度联合基金项目[WJ2019M039];2019年黄石市医疗卫生科技计划项目(编号:2019A21)。

摘　　要：【目的】探讨巨噬细胞集落刺激因子(M-CSF)和β-连环素(β-Catenin)因子在重度子痫前期(preeclampsia,PE)患者血清中的表达及其临床意义。【方法】选择早发重度PE(早发重度PE组)、晚发重度PE患者(晚发重度PE组)各51例,比较两组患者血清M-CSF、β-Catenin细胞因子表达水平、临床生化指标及妊娠并发症发生率。【结果】早发重度PE组患者血清M-CSF、β-Catenin因子表达水平均显著高于晚发重度PE组,其差异有统计学意义(P<0.05);Pearson相关性分析显示:M-CSF与β-Catenin因子在重度PE组患者血清中表达呈显著正相关(r=0.75,P<0.05)。早发重度PE组患者血肌酐(SCr)、血尿素氮(BUN)、血尿酸(UA)、24 h尿蛋白(24hpro)定量均显著高于晚发重度PE患者,其差异均有统计学意义(P<0.05);早发重度PE组患者并发症发生率为78.43%(40/51),显著高于晚发重度PE组的35.29%(18/51),其差异有统计学意义(χ^(2)=10.77,P=0.02)。【结论】M-CSF、β-Catenin在重度PE患者血清中异常表达,其在PE发病、进展中起协同作用,但早发型重度PE患者并发症发生率更高,临床对重度PE需要尽快明确诊断,采取积极的治疗措施,改善妊娠结局。【Objective】To explore the relationship between the expression of macrophage colony stimulating factor(M-CSF)and p-catenin(β-Catenin)in the serum of patients with severe pre-eclampsia(PE)and its clinical significance.【Methods】There were 51 patients with early-onset severe PE and 51 cases of late-onset severe PE were selected in each group.The serum M-CSF and β-Catenin cytokine expression levels,clinical biochemical indicators and pregnancy complications were compared between the two groups,and their interaction relationship was analyzed.【Results】The expression levels of serum M-CSF and β-Catenin factor in the early-onset severe PE group were higher than those in the late-onset severe PE group,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that the relationship of M-CSF and β-Catenin expression in the serum of patients with severe PE was significantly positively correlated(r=0.75,P=0.00<0.01).The quantitative levels of serum creatinine(SCr),blood urea nitrogen(BUN),blood uric acid(UA)and 24h urine protein(24hpro)in patients with early-onset severe PE were significantly higher than those in patients with late-onset severe PE,and the differences were statistically significant(P<0.05).The incidence of complications in the early-onset severe PE group was 78.43%(40/51),which was significantly higher than 35.29%(18/51)in the late-onset severe PE group,and the difference was statistically significant(χ^(2)=10.77,P=0.02).【Conclusion】The expression of serum M-CSF and β-Catenin in patients with severe preeclampsia plays a synergistic role in the pathogenesis of PE,and is closely related to the severity of the disease and the incidence of complications.Clinical diagnosis of severe PE needs to be confirmed as soon as possible,so active treatment measures can be put properly to improve pregnancy outcome.

关 键 词：子痫/诊断 巨噬细胞集落刺激因子/分析 蛋白质类/分析 

分 类 号：R714.245[医药卫生—妇产科学]