口服硫酸氨基葡萄糖、硫酸软骨素和双醋瑞因对成人大骨节病患者肾功能的影响  

Effect of glucosamine sulfate,chondroitin sulfate and diacetarine on renal function in adult patients with Kashin-Beck disease

作　　者：张琪 周海纯[2] 齐芳 崔丝露 曹艳红[1] 焦喆 刘宁[1] 李佳鑫 张鑫 于钧[1] Zhang Qi;Zhou Haichun;Qi Fang;Cui Silu;Cao Yanhong;Jiao Zhe;Liu Ning;Li Jiaxin;Zhang Xin;Yu Jun(Institute for Kashin-Beck Disease Control and Prevention,Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,Harbin Medical University,Harbin 150081,China;Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心大骨节病防治研究所,150081 [2]黑龙江中医药大学第二临床医学院,哈尔滨150001

出　　处：《中华地方病学杂志》2021年第11期866-870,共5页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81872564);黑龙江省应用技术研究与开发计划重大项目(GA18C007)。

摘　　要：目的探讨硫酸氨基葡萄糖、硫酸软骨素和双醋瑞因对成人大骨节病患者尿中肾功指标[尿素(UREA)、肌酐(CREA)、尿微量蛋白(mALB)、N-乙酰-β-D-葡萄糖苷酶(NAG)]的影响。方法根据《大骨节病诊断》标准(WS/T 207-2010),于2019年在黑龙江省大骨节病病区选取Ⅰ度和Ⅱ度成人大骨节病患者,采用临床随机对照试验方法,按照年龄、性别、病情分度等条件采用随机数字表法分为3个治疗组[A组(硫酸氨基葡萄糖组)、B组(硫酸软骨素组)和C组(双醋瑞因组)]。在治疗0、90和180 d时采集患者空腹中段晨尿,使用全自动生化分析仪检测UREA、CREA、mALB及NAG的水平,并分析上述指标异常率。结果治疗0 d,3组分别为118、99、116人;治疗90 d,3组分别剩余115、93、106人;治疗180 d,3组分别剩余95、80、93人。治疗0、180 d时,3组患者UREA、CREA、NAG、mALB水平比较差异均无统计学意义(H=0.055、0.923、0.276、1.125,1.635、3.873、1.045、4.135,P均>0.05)。治疗90 d时,3组患者CREA水平比较差异无统计学意义(H=1.719,P>0.05),C组患者UREA、NAG水平均高于B组(P均<0.05),B组患者mALB水平高于C组(P<0.05)。治疗90 d时,3组患者mALB水平均低于0 d(Z=-2.858、-3.217、-2.124,P均<0.05),NAG水平均高于0 d(Z=-3.700、-2.222、-4.672,P均<0.05),C组患者UREA水平高于0 d(Z=-2.393,P<0.05)。治疗180 d时,3组患者CREA水平均高于0 d(Z=-5.853、-6.984、-6.255,P均<0.05),3组患者mALB水平均低于0 d(Z=-3.785、-2.624、-3.427,P均<0.05)。治疗180 d时,3组患者CREA异常率均高于治疗0、90 d(χ^(2)=39.499、37.707,71.534、57.959,58.160、55.129,P均<0.05),治疗0 d与治疗90 d的CREA异常率比较差异均无统计学意义(χ^(2)=0.004、2.068、0.053,P均>0.05)。A、C两组患者治疗90 d的NAG异常率均高于治疗0 d(χ^(2)=8.999、11.227,P均<0.05)。C组患者治疗180 d的NAG异常率高于治疗0 d(χ^(2)=5.006,P<0.05)。A、C两组患者治疗90 d的NAG异常率与治疗180 d比较差异均�Objective To investigate the effects of glucosamine sulfate,chondroitin sulfate and diacetarine on urinary renal function indexes UREA,creatinine(CREA),urinary microprotein(mALB)and N-acetyl-β-D-glucosidase(NAG)in adult patients with Kashin-Beck disease.Methods According to the criteria of"Diagnosis of Kashin-Beck Disease"(WS/T 207-2010),adult patients with degreesⅠandⅡKashin-Beck disease in Heilongjiang Province were selected in 2019.They were randomly divided into three treatment groups according to age,gender,disease classification and other condition by clinical randomized controlled trial,group A(glucosamine sulfate group),group B(chondroitin sulfate group)and group C(diacetarine group).Fasting mid-morning urine was collected at 0,90 and 180 days of treatment.The levels of UREA,CREA,mALB and NAG were measured using an automatic biochemical analyzer.And the abnormal rates of the above indexes were analyzed.Results At 0 day of treatment,there were 118,99 and 116 people in the 3 groups,respectively;after 90 days of treatment,115,93 and 106 people remained in the 3 groups;after 180 days of treatment,95,80 and 93 people remained in the 3 groups.The results showed that there was no significant difference in the levels of UREA,CREA,NAG and mALB among the 3 groups at 0 and 180 days of treatment(H=0.055,0.923,0.276,1.125,1.635,3.873,1.045,4.135,P>0.05).After 90 days of treatment,there was no significant difference in CREA level among the 3 groups(H=1.719,P>0.05),the levels of UREA and NAG in group C were higher than those in group B(P<0.05),and the level of mALB in group B was higher than that in group C(P<0.05).The comparison results of all indexes before and after treatment showed that after 90 days of treatment,the levels of mALB in the 3 groups were lower than those of 0 day(Z=-2.858,-3.217,-2.124,P<0.05),the levels of NAG were higher than those of 0 day(Z=-3.700,-2.222,-4.672,P<0.05);and the level of UREA in group C was higher than that of 0 day(Z=-2.393,P<0.05).After 180 days of treatment,the levels of CRE

关 键 词：地方性变形性骨关节炎 药物治疗 肾功能 

分 类 号：R684.1[医药卫生—骨科学]