青海高原成人大骨节病患者血清IL-2和IL-6检测结果分析  

Analysis of serum IL-2 and IL-6 in adult patients with Kashin-Beck disease in Qinghai Plateau

作　　者：周昕[1] 李强[1] 蒲光兰[1] 时雨 喇翠玲[1] 马丽[1] 杨旭欣[1] 徐立青[1] 樊迪 赵志军[1] Zhou Xin;Li Qiang;Pu Guanglan;Shi Yu;La Cuiling;Ma Li;Yang Xuxin;Xu Liqing;Fan Di;Zhao Zhijun(Department for Endemic Disease Prevention and Control,Qinghai Institute for Endemic Disease Prevention and Control,Xining 810021,China;Graduate School,Qinghai University,Xining 810010,China)

机构地区：[1]青海省地方病预防控制所地方病预防控制科,西宁810021 [2]青海大学研究生院,西宁810010

出　　处：《中华地方病学杂志》2021年第11期877-879,共3页Chinese Journal of Endemiology

基　　金：青海省基础研究项目(2017-ZJ-770);青海省卫生与计划生育委员会指导性课题(2017-wjzdx-38)。

摘　　要：目的了解青海高原成人大骨节病(KBD)患者血清白细胞介素(IL)-2和IL-6改变情况,为科学防治高原KBD提供理论依据。方法在青海省海南藏族自治州兴海县、贵德县KBD病区,根据《大骨节病诊断》(WS/T 207-2010),分别选取18岁以上成人KBD患者及健康人群作为KBD组和对照组。采集两组人群空腹肘静脉血,采用酶联免疫吸附试验(ELISA)法检测血清IL-2和IL-6水平。结果共调查病区人群193人,其中KBD组114人、对照组79人,两组间年龄、性别比例比较差异均无统计学意义(t=0.204,χ^(2)=2.547,P均>0.05)。KBD组患者血清IL-2、IL-6水平分别为(572.21±172.92)、(42.35±15.86)pg/ml,与对照组[(511.28±173.22)、(51.96±17.18)pg/ml]比较,差异均有统计学意义(t=2.404、3.999,P均<0.05)。结论青海高原成人KBD患者血清IL-2水平增高、IL-6水平降低,二者可能参与成人KBD的炎性反应。Objective To understand the changes of serum interleukin(IL)-2 and IL-6 in adult patients with Kashin-Beck disease(KBD)in Qinghai Plateau,and to provide scientific basis for scientific prevention and treatment of plateau KBD.Methods According to the"Diagnosis of Kashin-Beck Disease"(WS/T 207-2010),adult KBD patients and healthy people over 18 years old were selected as KBD group and control group,respectively,in KBD disease areas of Xinghai County and Guide County,Hainan Tibetan Autonomous Prefecture,Qinghai Province.Fasting cubital venous blood was collected from the people of two groups,and the levels of serum IL-2 and IL-6 were determined by enzyme-linked immunosorbent assay(ELISA).Results A total of 193 people were surveyed,including 114 people in KBD group and 79 people in control group.There was no significant difference in age and sex ratio between the two groups(t=0.204,χ^(2)=2.547,P>0.05).The serum IL-2 and IL-6 levels of the KBD group were(572.21±172.92),(42.35±15.86)pg/ml,respectively;compared with the control group[(511.28±173.22),(51.96±17.18)pg/ml],the differences were statistically significant(t=2.404,3.999,P<0.05).Conclusion The serum IL-2 level is increased and IL-6 level is decreased in adult KBD patients in Qinghai Plateau,both of which may be involved in the inflammatory reaction of adult KBD.

关 键 词：地方性变形性骨关节炎 成人 白细胞介素 

分 类 号：R684.1[医药卫生—骨科学]