癌症治疗中小干扰RNA治疗方法及载体的研究概况  

Research advances of therapeutic strategies and delivery vectors of siRNA in cancer treatment

作　　者：周远非 金勇[1] 金光玉 孙丹丹[1] 孙景鑫 全姬善[1] ZHOU Yuan-fei;JIN Yong;JIN Guang-yu;SUN Dan-dan;SUN Jing-xin;QUAN Ji-shan(College of Pharmacy,Yanbian University,Jilin Yanji 133000,China;Department of Radiology,Yanbian University Hospital,Jilin Yanji 133000,China)

机构地区：[1]延边大学药学院,吉林延吉133000 [2]延边大学附属医院放射科,吉林延吉133000

出　　处：《中国医院药学杂志》2021年第22期2379-2384,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81560578,81860304);吉林省科技厅自然科学基金项目(编号:20190201251JC)。

摘　　要：癌症是当前危害人类健康的主要疾病之一。采用传统的手术、化疗等治疗手段无法完全根除或杀死肿瘤细胞,且易发生转移和复发等现象。由于小干扰RNA(siRNA)介导的基因沉默技术可通过破坏目的蛋白mRNA的完整性,达到抑制疾病相关基因表达的作用;且siRNA因其高效性、特异性特点以及作为基因药物的巨大潜力,备受研究者的青睐。本文就小干扰RNA技术的作用机制、小干扰RNA药物传递系统及其在抗肿瘤领域的相关应用进行综述。Cancer is one of the major killers endangering human health.Traditional surgery,chemotherapy and other treatments cannot completely eradicate or kill tumor cells,especially during metastasis and recurrence.Gene silencing mediated by small interfering RNAs(siRNAs)achieves antitumor effect by destroying the mRNA integrity of tumor-related genes so that tumor cell proliferation becomes suppressed.siRNA has attracted much attention as a genetic tool due to its high efficiency and specificity.This review focused upon the mechanism of siRNA,siRNA drug delivery system and its applications in the field of anti-tumor research.

关 键 词：小干扰RNA 基因载体 沉默效率 联合治疗 

分 类 号：R94[医药卫生—药剂学]