肠道菌群在肥胖导致的女性生育障碍中的作用研究进展  

Research progress on the role of gut microbiota in female fertility disorders caused by obesity

作　　者：李慧[1] 杨庆岭[1] 孙莹璞[1] Li Hui;Yang Qingling;Sun Yingpu(The Reproductive Medicine of Center of the First Affiliated Hospital of Zhengzhou University,Henan Key Laboratory of Reproduction and Genetics,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院生殖医学中心,河南省生殖与遗传病重点实验室,450052

出　　处：《中华生殖与避孕杂志》2021年第10期910-914,共5页Chinese Journal of Reproduction and Contraception

摘　　要：肥胖通过多种复杂的机制影响着女性生育能力,如肥胖引起的慢性低度炎症和胰岛素抵抗(insulin resistence,IR),以及随之而来的高雄激素血症可影响排卵、子宫内膜容受性,从而导致不孕。近年来研究表明,肠道菌群作为一个新的影响因素在肥胖的发生、发展中发挥重要作用,通过改善肠道菌群来减轻体质量可改善女性生育能力,但其在肥胖导致的女性生育障碍中的作用具体机制仍需进一步研究。本文围绕肠道菌群在肥胖导致的女性生育障碍中的作用展开综述。Obesity has an effect on fertility in women through multiple and complex mechanisms.Briefly,chronic low-grade inflammation and insulin resistance caused by obesity,as well as subsequent hyperandrogenemia,can affect ovulation and endometrial receptivity,and ultimately infertility.Recent studies have shown that the gut microbiota plays an important role in the occurrence and development of obesity.Weight loss by improving gut microbiota can also improve fertility in women.Further studies are needed to investigate the role and mechanism of gut microbiota in the development and progression of female fertility disorder caused by obesity.

关 键 词：肥胖 不孕症 肠道菌群 

分 类 号：R589.2[医药卫生—内分泌] R711.6[医药卫生—内科学]