多囊卵巢综合征的啮齿类动物模型  

Rodent models of polycystic ovary syndrome

作　　者：廖宝莹 齐新宇[1] 乔杰[1] 庞艳莉 Liao Baoying;Qi Xinyu;Qiao Jie;Pang Yanli(Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Key Laboratory of Assisted Reproduction(Peking University),Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest,Chinese Academy of Medical Sciences,Beijing 100191,China)

机构地区：[1]北京大学第三医院妇产科生殖医学中心,国家妇产疾病临床医学研究中心(北京大学第三医院),辅助生殖教育部重点实验室(北京大学),北京市生殖内分泌与辅助生殖技术重点实验室,中国医学科学院卵成熟障碍综合诊治研究创新单元,100191

出　　处：《中华生殖与避孕杂志》2021年第10期948-955,共8页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2018YFC1003900,2018YFC1003200);中国医学科学院卵成熟障碍综合诊治研究创新单元(2019-I2M-5-001);北京大学第三医院临床重点项目(BYSYZD2019020)。

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄女性常见的生殖内分泌疾病,其病因复杂,临床异质性高。代谢异常是PCOS的重要特征,在PCOS发病中有重要作用。本文主要综述PCOS啮齿类动物模型的造模方法及其生殖内分泌和代谢特征,讨论了各种模型所适用的研究类型,为PCOS病因学研究及防治策略探索所需啮齿类动物模型的选择提供参考。Polycystic ovary syndrome(PCOS)is a common reproductive endocrine disease in women of reproductive age.Its etiology is complex and its clinical heterogeneity is high.Metabolic abnormality is an important characteristic of PCOS and plays a crucial role in the pathogenesis of PCOS.This paper mainly reviews the reproductive endocrine disorders and metabolic abnormalities of rodent models induced by various modeling methods,discusses the applicable research of various models and provides a reference for the selection of PCOS rodent models,which matter in the etiology research and therapy exploration of PCOS.

关 键 词：多囊卵巢综合征 啮齿类动物模型 代谢异常 生殖内分泌紊乱 造模方法 

分 类 号：R711.75[医药卫生—妇产科学] R-332[医药卫生—临床医学]