右美托咪定与咪达唑仑术前镇静对前列腺患者术后认知功能的影响  

Effect of Preoperative Sedation With Dexmedetomidine and Midazolam on Postoperative Cognitive Function of Prostate Patients

作　　者：刘秀丽 LIU Xiu-li(Department of Anesthesiology,Tai'an Hospital of Traditional Chinese Medicine,Shandong Tai'an,271000,China)

机构地区：[1]泰安市中医医院麻醉科,山东泰安271000

出　　处：《中华养生保健》2021年第16期6-7,196,共3页CHINESE HEALTH CARE

摘　　要：目的探究右美托咪定与咪达唑仑术前镇静对前列腺患者术后认知功能的影响。方法将2018年1月~2021年1月在泰安市中医医院进行前列腺电切术治疗的86例前列腺增生症患者作为观察对象,依据奇偶数将患者随机分为参照组和观察组各43例,参照组患者给予咪达唑仑进行术前镇静,观察组患者给予右美托咪定进行术前麻醉,观察两组患者术中不同时间段生命体征变化情况及手术前后认知功能变化情况。结果随着给药时间的延长,参照组与观察组患者的MAP逐渐下降,不同时间段两组患者的MAP差异无统计学意义(P>0.05),参照组患者手术过程中HR波动较大,观察组患者存在一定的心脏抑制,给药10 min、30 min及手术结束时HR虽然低于参照组(P<0.05),但未出现明显的波动,两组患者手术过程中SpO2水平差异无统计学意义(P>0.05);术后1 h、3 h,两组患者简易智能精神状态检查量表(MMSE)评分均低于手术前,参照组患者明显低于观察组(P<0.05)。结论右美托咪定用于术前镇静,有助于维持前列腺术中患者心率的稳定,对患者术后认知功能的影响更小。Objective To explore the effect of dexmedetomidine and midazolam on postoperative cognitive function of prostate patients.Methods From January 2018 to January 2021,86 patients with benign prostatic hyperplasia were treated by transurethral resection of prostate in Tai'an Hospital of Traditional Chinese Medicine as observation objects.According to odd and even numbers,the patients were randomly divided into reference group and observation group,with 43 cases in each group.The patients in the reference group were given midazolam for preoperative sedation,while the patients in the observation group were given dexmedetomidine for preoperative anesthesia.The changes of vital signs and cognitive function before and after operation were observed.Results With the extension of administration time,MAP of patients in the reference group and the observation group decreased gradually,but there was no significant difference between the two groups in different time periods(P>0.05).HR of patients in the reference group fluctuated greatly during operation,while that of patients in the observation group had certain cardiac depression.Although HR was lower than that of the reference group at 10 min,30 min after administration and at the end of operation(P<0.05),there was no obvious fluctuation.At 1 h and 3 h after operation,MMSE scores of patients in both groups were lower than those before operation,and those in the reference group were significantly lower than those in the observation group(P<0.05).Conclusion Dexmedetomidine is used for preoperative sedation,which is helpful to maintain the stability of heart rate in patients undergoing prostate operation,and has less effect on postoperative cognitive function.

关 键 词：右美托咪定 咪达唑仑 术前镇静 前列腺电切术 认知功能 

分 类 号：R614[医药卫生—麻醉学]