丙型病毒性肝炎患者并发认知损害发病机制的研究进展  

Advances in the Pathogenesis of Cognitive Impairment in Patients with Hepatitis C Virus

作　　者：刘婧 贺娜 刘曼玲[1] 弥曼[1] LIU Jing;HE Na;LIU Man-ling;MI Man(Xi’an Medical University,Xi’an 710021,China;The First Affiliated Hospital of Xi’an Medical University,Xi’an 710006,China)

机构地区：[1]西安医学院,西安710021 [2]西安医学院第一附属医院消化内科,西安710006

出　　处：《中国临床神经科学》2021年第6期661-665,共5页Chinese Journal of Clinical Neurosciences

基　　金：佑安肝病感染病专科医疗联盟专项基金(编号:LM202003)。

摘　　要：丙型肝炎病毒感染是一个严重的全球公共卫生问题。随着直接抗病毒药物的推出,慢性丙型病毒性肝炎的治疗模式正在逐步发生改变,慢性丙型病毒性肝炎患者的健康相关生活质量也成为临床研究者们关注的热点之一,而伴发认知损害也是影响慢性丙型病毒性肝炎患者生活质量的重要因素之一。目前慢性丙型病毒性肝炎患者合并认知损害发病机制尚未明确,文中就慢性丙型病毒性肝炎患者发生认知损害的可能机制研究进行综述,为治疗认知损害和改善患者生活质量等提供新思路。Hepatitis C virus(HCV)infection is a serious public health problem.With the appearance of direct-acting antivirals agents(DAAs),breakthroughs have been achieved in the antiviral therapy for hepatitis C and hepatitis C patients can be cured completely.The health-related quality of life of chronic Hepatitis C(CHC)patients has become one of the hot topics of interest for clinical researchers.Cognitive declines in HCV-infected patients could severely affect an individual’s social and physical activities,further influencing the quality of life of patients,and the pathogenesis of it is still unclear.The possible mechanisms of cognitive impairment in patients with Hepatitis C Virus were reviewed to provide new ideas for the treatment of HCV-related cognitive impairment and improving the quality of life of CHC patients.

关 键 词：丙型肝炎病毒 认知损害 生活质量 发病机制 

分 类 号：R512.63[医药卫生—内科学] R749.2[医药卫生—临床医学]