额颞叶痴呆的正电子发射断层显像分子影像学研究进展  

Molecular Imaging Progress of Positron Emission Tomography in Frontotemporal Dementia

作　　者：林华媚 吴平 左传涛 LIN Hua-mei;WU Ping;ZUO Chuan-tao(PET Centre,Huashan Hospital,Fudan University,Shanghai 200235,China)

机构地区：[1]复旦大学附属华山医院PET中心,上海200235

出　　处：《中国临床神经科学》2021年第6期686-689,695,共5页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:81771483,81971641);上海申康医院发展中心临床三年行动计划资助课题(编号:SHDC2020,CR1038B);上海市卫生健康委老龄化和妇儿健康研究专项课题(编号:2020YJZX0111)。

摘　　要：额颞叶痴呆(FTD)是与额颞叶变性相关的一组以认知损害、行为异常、语言障碍为主要表现,同时可以合并锥体外系损害和运动神经元病的临床综合征。其常见的3种临床分型包括行为异常型额颞叶痴呆、原发性进行性失语、额颞叶痴呆合并运动障碍综合征。目前,诊断FTD主要根据临床表现、评分量表、结构影像学检查等手段。但是,这些诊断方法缺乏特异性,也不利于疾病的早期诊断。PET分子影像学可以从分子水平实现疾病病理的在体可视化,有助于疾病的早期诊断和鉴别诊断。文中针对PET显像在额颞叶痴呆方面的应用和研究现状进行综述。Frontotemporal dementia(FTD)is a group of clinical syndromes related to frontotemporal lobe degeneration,which is mainly manifested by cognitive impairment,behavioral abnormality and language impairment,and can also be combined with extrapyramidal damage and motor neuron disease.The three common clinical subtypes of frontotemporal dementia include abnormal behavior,primary progressive aphasia,and frontotemporal dementia with dyspraxia syndrome.The diagnosis of FTD is mainly based on clinical manifestations,scoring scale,structural imaging examination and other means.These diagnostic methods lack specificity and are not conducive to the early diagnosis of the disease.PET molecular imaging can realize in vivo visualization of disease pathology at the molecular level,which is helpful for early diagnosis and differential diagnosis of disease.The application and research status of positron emission tomography in frontotemporal dementia were reviewed.

关 键 词：额颞叶痴呆 异常型额颞叶痴呆 原发性进行性失语 运动障碍综合征 正电子发射断层显像 分子影像学 

分 类 号：R817[医药卫生—影像医学与核医学]