儿童重症肺炎不同危重程度的凝血、免疫指标对比分析  

Comparative Analysis of Coagulation and Immune Indexes of Children with Severe Pneumonia in Different Severity

作　　者：牛红艳[1] 宋祥春 萨初然贵[1] 马丽娜 NIU Hongyan;SONG Xiangchun;SAchu Rangui;MA Lina(Department of Pediatrics Chifeng Hospital,Chifeng,Inner Mongolia Autonomous Region,024000 China)

机构地区：[1]赤峰市医院儿科,内蒙古赤峰024000

出　　处：《系统医学》2021年第20期8-11,共4页Systems Medicine

基　　金：低分子肝素对儿童脓毒症患者凝血功能、炎症因子、免疫功能的影响(20200574)。

摘　　要：目的探讨分析儿童重症肺炎危重程度与凝血、免疫指标的相关性。方法选取50例于2018年6月-2020年10月在该院治疗的儿童重症肺炎患儿作为研究对象,根据小儿危重病例评分法(PCIS)评分将患者分为两组:观察组25例患者,PCIS评分≤80分;对照组25例患者,PCIS评分>80分。比较两组患者的凝血指标:D-二聚体(D-D)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、血小板计数(PLT)、纤维蛋白原(Fib)、人可溶性P选择素(sPs),免疫指标:免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、CD4+、补体C4及补体C3。结果观察组的D-D(2.54±0.49)mg/L、sPs(173.23±82.47)ng/mL比对照组(0.68±0.06)mg/L、(75.98±34.75)ng/mL高,PLT(221.37±49.18)×10^(9)/L比对照组(339.32±40.64)×10^(9)/L低,差异有统计学意义(t=18.839、5.433、9.244,P<0.05);观察组的CD4+(41.04±7.08)、IgM(0.57±0.11)g/L、IgA(1.17±0.23)g/L、IgG(8.66±1.67)g/L、补体C4(0.13±0.04)g/L、补体C3(0.96±0.16)g/L比对照组(53.12±7.05)、(1.38±0.18)g/L、(2.24±0.25)g/L、(11.83±1.85)g/L、(0.86±0.11)g/L、(1.52±0.19)g/L低,差异有统计学意义(t=6.045、19.199、15.749、6.360、31.184、11.272,P<0.05)。结论儿童重症肺炎危重程度与患者凝血功能及免疫功能之间存在显著相关性,临床应对免疫指标及凝血指标予以关注,以为临床疾病诊断及治疗提供参考。Objective To explore and analyze the correlation between the severity of severe pneumonia in children and blood coagulation and immune indicators.Methods Fifty children with severe pneumonia in children who were treated in the hospital from June 2018 to October 2020 were selected as the research objects,and the patients were divided into two groups according to the Pediatric Critical Case Score(PCIS)score:observation group 25 cases with PCIS score≤80 points;25 patients in the control group,PCIS scores>80 points.Compare the coagulation indexes of the two groups of patients:D-dimer(DD),prothrombin time(PT),activated partial thromboplastin time(APTT),platelet count(PLT),fibrinogen(Fib),human solubility P-selectin(sPs),immune indicators:immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),CD4+,complement C4 and complement C3.Results D-D(2.54±0.49)mg/L and sPs(173.23±82.47)ng/mL of the observation group were higher than those of the control group(0.68±0.06)mg/L,(75.98±34.75)ng/mL,and PLT(221.37±49.18)×10^(9)/L was lower than the control group(339.32±40.64)×10^(9)/L,and the difference was statistically significant(t=18.839,5.433,9.244;P<0.05);CD4+(41.04±7.08),IgM(0.57±0.11)g/L in the observation group,IgA(1.17±0.23)g/L,IgG(8.66±1.67)g/L,complement C4(0.13±0.04)g/L,complement C3(0.96±0.16)g/L than the control group(53.12±7.05),(1.38±0.18)g/L,(2.24±0.25)g/L,(11.83±1.85)g/L,(0.86±0.11)g/L,(1.52±0.19)g/L were low,the difference was statistically significant(t=6.045,19.199,15.749,6.360,31.184,11.272,P<0.05).Conclusion There is a significant correlation between the severity of severe pneumonia in children and the coagulation function and immune function of patients.Clinical attention should be paid to immune and coagulation indicators to provide reference for the diagnosis and treatment of clinical diseases.

关 键 词：儿童重症肺炎 凝血功能 免疫指标 相关性 

分 类 号：R72[医药卫生—儿科]